Electrospun Orodispersible Films of Isoniazid for Pediatric Tuberculosis Treatment

被引:44
作者
Chachlioutaki, Konstantina [1 ]
Tzimtzimis, Emmanouil K. [2 ]
Tzetzis, Dimitrios [2 ]
Chang, Ming-Wei [3 ]
Ahmad, Zeeshan [4 ]
Karavasili, Christina [1 ]
Fatouros, Dimitrios G. [1 ]
机构
[1] Aristotle Univ Thessaloniki, Dept Pharmaceut Sci, Lab Pharmaceut Technol, GR-54124 Thessaloniki, Greece
[2] Int Hellen Univ, Sch Sci & Technol, Digital Mfg & Mat Characterizat Lab, 14km Thessaloniki N Moudania, GR-57001 Thermi, Greece
[3] Univ Ulster, Nanotechnol & Integrated Bioengn Ctr, Jordanstown Campus, Newtownabbey BT37 0QB, North Ireland
[4] De Montfort Univ, Leicester Sch Pharm, Leicester LE1 9BH, Leics, England
关键词
orodispersible films; electrospinning; pediatric drug delivery; isoniazid; tuberculosis; FORMULATION; PULLULAN; OPTIMIZATION; MEDICINES; DELIVERY; THERAPY; FIBERS; SODIUM; FOOD;
D O I
10.3390/pharmaceutics12050470
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Child-appropriate dosage forms are critical in promoting adherence and effective pharmacotherapy in pediatric patients, especially those undergoing long-term treatment in low-resource settings. The present study aimed to develop orodispersible films (ODFs) for isoniazid administration to children exposed to tuberculosis. The ODFs were produced from the aqueous solutions of natural and semi-synthetic polymer blends using electrospinning. The spinning solutions and the resulting fibers were physicochemically characterized, and the disintegration time and isoniazid release from the ODFs were assessed in simulated salivary fluid. The ODFs comprised of nanofibers with adequate thermal stability and possible drug amorphization. Film disintegration occurred instantly upon contact with simulated salivary fluid within less than 15 s, and isoniazid release from the ODFs in the same medium followed after the disintegration profiles, achieving rapid and total drug release within less than 60 s. The ease of administration and favorable drug loading and release properties of the ODFs may provide a dosage form able to facilitate proper adherence to treatment within the pediatric patient population.
引用
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页数:14
相关论文
共 49 条
[1]   Electrospinning of Sodium Alginate-Pectin Ultrafine Fibers [J].
Alborzi, Solmaz ;
Lim, Loong-Tak ;
Kakuda, Yuiuo .
JOURNAL OF FOOD SCIENCE, 2010, 75 (01) :C100-C107
[2]   Synthesis and characterization of pectin derivative with antitumor property against Caco-2 colon cancer cells [J].
Almeida, Elizangela A. M. S. ;
Facchi, Suelen P. ;
Martins, Alessandro F. ;
Nocchi, Samara ;
Schuquel, Ivania T. A. ;
Nakamura, Celso V. ;
Rubira, Adley F. ;
Muniz, Edvani C. .
CARBOHYDRATE POLYMERS, 2015, 115 :139-145
[3]   Structure and mechanical properties of sodium and calcium caseinate edible active films with carvacrol [J].
Arrieta, Marina P. ;
Peltzer, Mercedes A. ;
del Carmen Garrigos, Maria ;
Jimenez, Alfonso .
JOURNAL OF FOOD ENGINEERING, 2013, 114 (04) :486-494
[4]   Adherence to isoniazid preventive therapy among child contacts in Rwanda: A mixed-methods study [J].
Birungi, Francine Mwayuma ;
Graham, Stephen Michael ;
Uwimana, Jeannine ;
Musabimana, Angele ;
van Wyk, Brian .
PLOS ONE, 2019, 14 (02)
[5]   Electrospun amorphous solid dispersions of meloxicam: Influence of polymer type and downstream processing to orodispersible dosage forms [J].
Casian, Tibor ;
Borbas, Eniko ;
Ilyes, Kinga ;
Demuth, Balazs ;
Farkas, Attila ;
Rapi, Zsolt ;
Bogdan, Catalina ;
Iurian, Sonia ;
Toma, Valentin ;
Stiufiuc, Rares ;
Farkas, Balazs ;
Balogh, Attila ;
Marosi, Gyorgy ;
Tomuta, Ioan ;
Nagy, Zsombor Kristof .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 569
[6]   Electrospun cellulose acetate fibers containing chlorhexidine as a bactericide [J].
Chen, Liang ;
Bromberg, Lev ;
Hatton, T. Alan ;
Rutledge, Gregory C. .
POLYMER, 2008, 49 (05) :1266-1275
[7]   Tuberculosis preventive therapy in the era of HIV infection: Overview and research priorities [J].
Churchyard, Gavin J. ;
Scano, Fabio ;
Grant, Alison D. ;
Chaisson, Richard E. .
JOURNAL OF INFECTIOUS DISEASES, 2007, 196 :S52-S62
[8]   Continuous manufacturing of orally dissolving webs containing a poorly soluble drug via electrospinning [J].
Domokos, Andras ;
Balogh, Attila ;
Denes, Daniel ;
Nyerges, Gyula ;
Zodi, Levente ;
Farkas, Balazs ;
Marosi, Gyorgy ;
Nagy, Zsombor Kristof .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 130 :91-99
[9]   Characterization and Optimization of Orodispersible Mosapride Film Formulations [J].
ElMeshad, Aliaa N. ;
El Hagrasy, Arwa S. .
AAPS PHARMSCITECH, 2011, 12 (04) :1384-1392
[10]   Comparative investigations on different polymers for the preparation of fast-dissolving oral films [J].
Garsuch, Verena ;
Breitkreutz, Joerg .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2010, 62 (04) :539-545