Chemical Biology of H2S Signaling through Persulfidation

被引：770

作者：

Filipovic, Milos R. ^{[1
,2
]}

Zivanovic, Jasmina ^{[1
,2
]}

Alvarez, Beatriz ^{[3
,4
]}

Banerjee, Ruma ^{[5
]}

机构：

[1] Univ Bordeaux, IBGC, UMR 5095, F-33077 Bordeaux, France

[2] CNRS, IBGC, UMR 5095, F-33077 Bordeaux, France

[3] Univ Republica, Lab Enzimol, Fac Ciencias, Montevideo 11400, Uruguay

[4] Univ Republica, Ctr Free Rad & Biomed Res, Montevideo 11400, Uruguay

[5] Univ Michigan, Dept Biol Chem, Med Sch, Ann Arbor, MI 48109 USA

来源：

CHEMICAL REVIEWS | 2018年 / 118卷 / 03期

关键词：

CYSTATHIONINE BETA-SYNTHASE; HYDROGEN-SULFIDE H2S; 2ND DISSOCIATION-CONSTANT; CYTOCHROME-C-OXIDASE; ENDOPLASMIC-RETICULUM STRESS; SULFATE-REDUCING BACTERIA; ESCHERICHIA-COLI THIOREDOXIN; THIOSULFATE SULFURTRANSFERASE RHODANESE; ELECTRON-PARAMAGNETIC-RESONANCE; ISCHEMIA-REPERFUSION INJURY;

D O I：

10.1021/acs.chemrev.7b00205

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for understanding the physiological and pharmacological effects of H2S. Due to the inherent instability of persulfides, their chemistry is understudied. In this review, we discuss the biologically relevant chemistry of H2S and the enzymatic routes for its production and oxidation. We cover the chemical biology of persulfides and the chemical probes for detecting them. We conclude by discussing the roles ascribed to protein persulfidation in cell signaling pathways.

引用

页码：377 / 461

页数：85

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