Omega-3 fatty acids and their lipid mediators: Towards an understanding of resolvin and protectin formation Omega-3 fatty acids and their resolvin/protectin mediators

被引：203

作者：

Weylandt, Karsten H. ^{[1
,2
,3
]}

Chiu, Cheng-Ying ^{[1
,2
,3
]}

Gomolka, Beate ^{[1
]}

Waechter, Simon F. ^{[1
,2
,3
]}

Wiedenmann, Bertram ^{[1
]}

机构：

[1] Charite, Rudolf Virchow Hosp, Dept Gastroenterol Hepatol & Endocrinol, D-13353 Berlin, Germany

[2] Massachusetts Gen Hosp, Lab Lipid Med & Technol, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Boston, MA USA

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2012年 / 97卷 / 3-4期

关键词：

Omega-3; n-3; PUFA; Resolvins; Protectins; 17-HDHA; 18-HEPE; EPITHELIAL-CELL SURVIVAL; N-3; FATTY-ACIDS; DAMPENS AIRWAY INFLAMMATION; FAT-1 TRANSGENIC MICE; DOCOSAHEXAENOIC ACID; NEUROPROTECTIN D1; ANTIINFLAMMATORY ACTIONS; ELEVATED OMEGA-3-FATTY-ACIDS; INSULIN-RESISTANCE; OXIDATIVE STRESS;

D O I：

10.1016/j.prostaglandins.2012.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have long been associated with decreased inflammation and are also implicated in the prevention of tumorigenesis. Conventional thinking attributed this mainly to a suppressive effect of these fatty acids on the formation of arachidonic acid-derived prostaglandins and leukotrienes. Recent years have seen the discovery of a new class of inflammation-dampening and resolution-promoting n-3 PUFA-derived lipid mediators called resolvins and protectins. Chemically, these compounds are hydroxylated derivatives of the parent n-3 PUFA eicosapentaenoic acid (EPA) for the E-resolvins, and docosahexaenoic acid (DHA) for the D-resolvins and protectin D1. While a relatively large number of these compounds have been identified and characterized until now, with differences in the positions of the hydroxyl-groups as well as in the chirality at the different carbon atoms, all compounds share common precursor metabolites. 17-hydroperoxydocosahexaenoic acid (17-H(p)DHA) for the DNA-derived compounds and 18-hydroperoxyeicosapentaenoic acid (18-H(p)EPE) for the EPA-derived compounds. In this review we summarize the current knowledge about EPA- and DHA-derived resolvins and protectins and explore the potential use of the pro-resolvins 17-hydroxydocosahexaenoic acid (17-HDHA) and 18-hydroxyeicosapentaenoic acid (18-HEPE) as indicators of anti-inflammatory n-3 PUFA mediator formation. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：73 / 82

页数：10

共 115 条

[1] Neuroprotectin D1 Induces Dephosphorylation of Bcl-xL in a PP2A-dependent Manner during Oxidative Stress and Promotes Retinal Pigment Epithelial Cell Survival [J].