A flexible radical approach to 5-substituted 4,5-dihydro-3H-pyrido[4,3-b]azepin-2-ones. Some mechanistic observations on the radical cyclisation-aromatisation process

被引：11

作者：

Petit, Laurent ^{[1
]}

Botez, Iuliana ^{[2
]}

Tizot, Andre ^{[2
]}

Zard, Samir Z. ^{[1
]}

机构：

[1] Ecole Polytech, UMR CNRS 7652, Lab Synth Organ, F-91128 Palaiseau, France

[2] Inst Rech Servier IdRS, F-78290 Croissy Sur Seine, France

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 26期

关键词：

Radical cyclisation; Radical addition; Xanthates; Pyridoazepinones; Peroxides; XANTHATES; INDOLES;

D O I：

10.1016/j.tetlet.2012.04.020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Variously substituted novel dihydropyridoazepinones have been prepared by an intermolecular radical addition followed by a radical cyclisation on a pyridine ring. The latter process involved the use of a combination of two different peroxides, an experimental contrivance resulting from a careful product analysis and a better understanding of the cyclisation step. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：3220 / 3224

页数：5

共 26 条

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