Analysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma

被引：23

作者：

Fernandez-Mateos, Javier ^{[1
,2
,3
,4
]}

Seijas-Tamayo, Raquel ^{[1
,2
]}

Adansa Klain, Juan Carlos ^{[1
,2
]}

Pastor Borgonon, Miguel ^{[5
]}

Perez-Ruiz, Elisabeth ^{[6
]}

Mesia, Ricard ^{[7
]}

del Barco, Elvira ^{[1
,2
]}

Salvador Coloma, Carmen ^{[5
]}

Rueda Dominguez, Antonio ^{[6
]}

Caballero Daroqui, Javier ^{[5
]}

Fernandez Ruiz, Encarnacion ^{[8
]}

Jesus Cruz-Hernandez, Juan ^{[1
,2
,3
,4
]}

Gonzalez-Sarmiento, Rogelio ^{[2
,3
,4
]}

机构：

[1] Univ Hosp Salamanca, IBSAL, Med Oncol Serv, Salamanca 37007, Spain

[2] Univ Salamanca, CSIC, SACYL, Biomed Res Inst Salamanca IBSAL, Salamanca 37007, Spain

[3] Univ Salamanca, Dept Med, IBSAL, Mol Med Unit, Salamanca 37007, Spain

[4] Univ Salamanca, CSIC, Inst Mol & Cellular Biol Canc IBMCC, Salamanca 37007, Spain

[5] Hosp Univ Politecn La Fe, Med Oncol Serv, Valencia 46026, Spain

[6] Agencia Sanitaria Hosp Costa Sol Marbella, Oncol Dept, Div Med Oncol, Marbella 29603, Spain

[7] Univ Barcelona, IDIBELL, Inst Catala Oncol, Med Oncol Dept, Barcelona 08908, Spain

[8] Agencia Sanitaria Hosp Costa Sol Marbella, Otolaryngol Dept, Marbella 29603, Spain

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

RISK-FACTORS; MOLECULAR-BIOLOGY; CANCER; EPIDEMIOLOGY; DISEASE;

D O I：

10.1038/s41598-017-07270-0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Head and neck squamous cell carcinoma (HNSCC) is the sixth cancer on incidence worldwide. Tobacco and alcohol consumption are the most classical risk factors associated with its development. Autophagy process has a dual effect both in tumourigenesis and tumour suppressing activity. To investigate the importance of this pathway in HNSCC susceptibility, a risk factor matched case-control association study was performed with four candidate polymorphisms in autophagy genes (ATG2B, ATG5, ATG10, ATG16L1). We found an association between the variant in ATG10 rs1864183 and a higher susceptibility to develop laryngeal cancer, ATG2B rs3759601 and pharyngeal cancer and ATG16L1 rs2241880 and oral carcinoma. ATG5 rs2245214 SNP was not associated with any location. Overall, our results indicate the importance of the autophagy pathway in the susceptibility of head and neck squamous cell carcinoma and demonstrate the heterogeneity between its locations encompassed under a single terminology.

引用

页数：8

共 32 条

[1]

[Anonymous], BIOMETRIKA

[2]

[Anonymous], CANC EPIDEMIOL BIOMA

[3] Genetic sequence variants and the development of secondary primary cancers in patients with head and neck cancers [J].

Azad, Abul Kalam ;

Bairati, Isabelle ;

Samson, Elodie ;

Cheng, Dangxiao ;

Cheng, Lu ;

Mirshams, Maryam ;

Savas, Sevtap ;

Waldron, John ;

Wang, Changshu ;

Goldstein, David ;

Xu, Wei ;

Meyer, Francois ;

Liu, Geoffrey .

CANCER, 2012, 118 (06) :1554-1565

[4] The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1 [J].

Boada-Romero, Emilio ;

Serramito-Gomez, Inmaculada ;

Sacristan, Maria P. ;

Boone, David L. ;

Xavier, Ramnik J. ;

Pimentel-Muinos, Felipe X. .

NATURE COMMUNICATIONS, 2016, 7

[5] Autophagy in colorectal cancer: An important switch from physiology to pathology [J].

Burada, Florin ;

Nicoli, Elena Raluca ;

Ciurea, Marius Eugen ;

Uscatu, Daniel Constantin ;

Ioana, Mihai ;

Gheonea, Dan Ionut .

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2015, 7 (11) :271-284

[6]

Cardesa A, 2011, ACTA DERMATOVEN ALP, V20, P161

[7] The role of autophagy in squamous cell carcinoma of the head and neck [J].

Cosway, Benjamin ;

Lovat, Penny .

ORAL ONCOLOGY, 2016, 54 :1-6

[8] Inflammation in the context of oral cancer [J].

Feller, L. ;

Altini, M. ;

Lemmer, J. .

ORAL ONCOLOGY, 2013, 49 (09) :887-892

[9]

Ganci F., 2012, Molecular genetics and biology of head and neck squamous cell carcinoma: implications for diagnosis, prognosis and treatment

[10] Autophagy: cellular and molecular mechanisms [J].

Glick, Danielle ;

Barth, Sandra ;

Macleod, Kay F. .

JOURNAL OF PATHOLOGY, 2010, 221 (01) :3-12

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