Nanotechniques in proteomics: Protein microarrays and novel detection platforms

The field of proteomics has undergone rapid advancements over the last decade and protein rnicroarrays have emerged as a promising technological platform for the challenging tasks of studying complex proteomes. Researchers have gone beyond traditional techniques and approached promising disciplines like nanotechnology to satisfy the growing demands of studying proteins in high-throughput format. Applications of nanotechnology in proteomics came from the need to detect low-abundant proteins in complex mixtures for sensitive, real-time and multiplexed detection platform. The scope of this article is to outline the current status and key technological advances of nanotechniques in protein microarrays. (C) 2011 Elsevier B.V. All rights reserved.