Amniotic fluid;
Bioavailability;
Placenta;
Polyphenols;
Proanthocyanidins;
TANDEM MASS-SPECTROMETRY;
GREEN TEA CATECHINS;
FOOD SOURCES;
IN-VITRO;
MOLECULAR-MECHANISMS;
URINARY-EXCRETION;
EXTRACT;
PROCYANIDINS;
POLYPHENOLS;
TISSUES;
D O I:
10.1002/mnfr.201300032
中图分类号:
TS2 [食品工业];
学科分类号:
0832 ;
摘要:
ScopePolyphenols have been demonstrated to provide health benefits affecting cellular and physiological processes. This study aims to evaluate the bioavailability and distribution of grape seed flavanol compounds during pregnancy and whether fetuses could be exposed to these compounds. Methods and resultsThe distribution of flavanols and their metabolites in rat plasma, liver, white adipose tissue, brain, amniotic fluid, placenta, and fetuses after 1 and 2 h of an acute intake of a grape seed proanthocyanidin extract was examined by LC-ESI-TOF/MS. Flavanols and their metabolites were widely distributed in both pregnant and nonpregnant rat plasma and tissues. In liver, the conjugated forms of flavanols were less available in pregnant than nonpregnant rats. Flavanol metabolites were abundant in maternal placenta but detected at low levels in fetuses and amniotic fluid. ConclusionFlavanol metabolization appears to be less active in the liver during pregnancy. Moreover, data indicated that transport across the placenta is not efficient and for flavanols and their metabolites, the placenta seems to act as a barrier. However, these compounds target the fetus and are excreted in the amniotic fluid.
机构:
Univ Glasgow, Fac Biomed & Life Sci, Div Ecol & Evolutionary Biol, Glasgow G12 8QQ, Lanark, ScotlandUniv Glasgow, Fac Biomed & Life Sci, Div Ecol & Evolutionary Biol, Glasgow G12 8QQ, Lanark, Scotland
Crozier, Alan
;
Jaganath, Indu B.
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h-index: 0
机构:
Malaysian Agr Res & Dev Inst, Biotechnol Res Ctr, Kuala Lumpur, MalaysiaUniv Glasgow, Fac Biomed & Life Sci, Div Ecol & Evolutionary Biol, Glasgow G12 8QQ, Lanark, Scotland
Jaganath, Indu B.
;
Clifford, Michael N.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Surrey, Fac Hlth & Med Sci, Ctr Nutr & Food Safety, Food Safety Res Grp, Guildford GU2 7XH, Surrey, EnglandUniv Glasgow, Fac Biomed & Life Sci, Div Ecol & Evolutionary Biol, Glasgow G12 8QQ, Lanark, Scotland
机构:
Univ Glasgow, Fac Biomed & Life Sci, Div Ecol & Evolutionary Biol, Glasgow G12 8QQ, Lanark, ScotlandUniv Glasgow, Fac Biomed & Life Sci, Div Ecol & Evolutionary Biol, Glasgow G12 8QQ, Lanark, Scotland
Crozier, Alan
;
Jaganath, Indu B.
论文数: 0引用数: 0
h-index: 0
机构:
Malaysian Agr Res & Dev Inst, Biotechnol Res Ctr, Kuala Lumpur, MalaysiaUniv Glasgow, Fac Biomed & Life Sci, Div Ecol & Evolutionary Biol, Glasgow G12 8QQ, Lanark, Scotland
Jaganath, Indu B.
;
Clifford, Michael N.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Surrey, Fac Hlth & Med Sci, Ctr Nutr & Food Safety, Food Safety Res Grp, Guildford GU2 7XH, Surrey, EnglandUniv Glasgow, Fac Biomed & Life Sci, Div Ecol & Evolutionary Biol, Glasgow G12 8QQ, Lanark, Scotland