Genome-wide association studies on serum sex steroid levels

被引：12
|
作者：
Vandenput, Liesbeth [1 ]
Ohlsson, Claes [1 ]
机构：
[1] Univ Gothenburg, Ctr Bone & Arthrit Res, Inst Med, Sahlgrenska Acad, SE-41345 Gothenburg, Sweden
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2014年 / 382卷 / 01期
关键词：
Genome-wide association studies; Testosterone; Estradiol; Sex hormone-binding globulin; Dehydroepiandrosterone; Hypogonadism; HORMONE-BINDING GLOBULIN; CAG-REPEAT POLYMORPHISM; ANDROGEN RECEPTOR GENE; POPULATION-BASED COHORT; LIFE-STYLE FACTORS; TESTOSTERONE LEVELS; DEHYDROEPIANDROSTERONE-SULFATE; SHBG GENE; ELDERLY-MEN; INTERINDIVIDUAL VARIATION;
D O I：
10.1016/j.mce.2013.03.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Even though the levels of circulating sex steroid hormones are to a large extent heritable, their genetic determinants are largely unknown. With the advent of genome-wide association studies (GWAS), much progress has been made and several genetic loci have been identified to be associated with serum levels of dehydroepiandrosterone sulfate, testosterone and sex hormone-binding globulin. The variants identified so far only explain a small amount of the overall heritability, but may help to elucidate the role of sex steroid hormones in common disorders such as hypogonadism, type 2 diabetes and hormone-sensitive cancers. This review provides an overview of the current state of knowledge of the genetic determinants of sex steroid hormones, with a focus on recent GWAS and brief directions for elucidating the remaining heritability. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：758 / 766
页数：9
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