Tumour microenvironment factors shaping the cancer metabolism landscape

被引：98

作者：

Anastasiou, Dimitrios ^{[1
]}

机构：

[1] Francis Crick Inst, Canc Metab Lab, 1 Midland Rd, London NW1 1AT, England

来源：

BRITISH JOURNAL OF CANCER | 2017年 / 116卷 / 03期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

tumour microenvironment; cancer metabolism; cancer cell metabolism; tumour metabolism; metabolism; metabolic profile; ARYL-HYDROCARBON RECEPTOR; PYRUVATE-CARBOXYLASE; CELL-GROWTH; GLUTAMINE-METABOLISM; AEROBIC GLYCOLYSIS; TRANSFORMED-CELLS; FATTY-ACIDS; HYPOXIA; ANTIOXIDANT; INHIBITION;

D O I：

10.1038/bjc.2016.412

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer cells exhibit metabolic alterations that distinguish them from healthy tissues and make their metabolic processes susceptible to pharmacological targeting. Although typical cell-autonomous features of cancer metabolism have been emerging, it is increasingly appreciated that extrinsic factors also influence the metabolic properties of tumours. This review highlights evidence from the recent literature to discuss how conditions within the tumour microenvironment shape the metabolic character of tumours.

引用

页码：277 / 286

页数：10

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