The neonatal Fc receptor plays a crucial role in the metabolism of IgG in livestock animals

被引：60

作者：

Cervenak, Judit ^{[1
]}

Kacskovics, Imre ^{[1
,2
]}

机构：

[1] Eotvos Lorand Univ, Fac Sci, Inst Biol, Dept Immunol, H-1117 Budapest, Hungary

[2] Eotvos Lorand Univ, Hungarian Acad Sci, Immunol Res Grp, H-1117 Budapest, Hungary

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2009年 / 128卷 / 1-3期

关键词：

IgG metabolism; Neonatal Fc receptor; Maternal immune transport; IMMUNOGLOBULIN TRANSPORT PATHWAY; BOVINE MAMMARY-GLAND; I-RELATED RECEPTOR; MEDIATED TRANSCYTOSIS; EPITHELIAL-CELLS; SMALL-INTESTINE; ALPHA-CHAIN; SERUM IGG; FUNCTIONAL EXPRESSION; PULMONARY DELIVERY;

D O I：

10.1016/j.vetimm.2008.10.300

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of the FcRn is fundamental in IgG metabolism. It is involved in transporting maternal immunity and protects IgG from fast degradation throughout life. While the acquisition of the humoral immunity through the transfer of IgG from mother to offspring shows species-specific differences, the mechanism how FcRn protects IgG from degradation is highly similar in all species analyzed so far. This review summarizes the current understanding of the FcRn-mediated IgG metabolism in livestock animals (cattle, sheep and pig) and point out those aspects that remain to be exposed for better understanding the function of this system in these species and also to take advantages of it for economical purposes. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：171 / 177

页数：7

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