Acute-on-Chronic Liver Failure From Chronic-Hepatitis-B, Who Is the Behind Scenes

被引：16

作者：

Li, Qian ^{[1
]}

Wang, Jun ^{[2
]}

Lu, Mengji ^{[3
]}

Qiu, Yuanwang ^{[4
]}

Lu, Hongzhou ^{[1
]}

机构：

[1] Shanghai Publ Hlth Clin Ctr, Dept Infect Dis, Shanghai, Peoples R China

[2] Jiangnan Univ, Fifth Peoples Hosp Wuxi, Ctr Clin Lab, Wuxi, Jiangsu, Peoples R China

[3] Univ Duisburg Essen, Univ Hosp Essen, Inst Virol, Essen, Germany

[4] Jiangnan Univ, Fifth Peoples Hosp Wuxi, Dept Hepatol, Wuxi, Jiangsu, Peoples R China

来源：

FRONTIERS IN MICROBIOLOGY | 2020年 / 11卷

关键词：

ACLF; HBV— hepatitis B virus; B cells; inflammation; cytokines storm; COLONY-STIMULATING FACTOR; E-ANTIGEN; CHINESE PATIENTS; CORE PROMOTER; T-CELLS; BACTERIAL TRANSLOCATION; SYSTEMIC INFLAMMATION; PATHOGEN RECOGNITION; PORTAL-HYPERTENSION; IMPROVES SURVIVAL;

D O I：

10.3389/fmicb.2020.583423

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Acute-on-chronic liver failure (ACLF) is an acute syndrome accompanied with decompensation of cirrhosis, organ failure with high 28-day mortality rate. Systemic inflammation is the main feature of ACLF, and poor outcome is closely related with exacerbated systemic inflammatory responses. It is well known that severe systemic inflammation is an important event in chronic hepatitis B (CHB)-ACLF, which eventually leads to liver injury. However, the initial CHB-ACLF events are unclear; moreover, the effect of these events on host immunity as well as that of immune imbalance on CHB-ACLF progression are unknown. Here, we investigate the initial events of ACLF progression, discuss possible mechanisms underlying ACLF progression, and provide a new model for ACLF prediction and treatment. We review the characteristics of ACLF, and consider its plausible immune predictors and alternative treatment strategies.

引用

页数：13

共 133 条

[1] Pathogen recognition and innate immunity [J].

Akira, S ;

Uematsu, S ;

Takeuchi, O .

CELL, 2006, 124 (04) :783-801

[2]

Alam A, 2017, J BIOMED RES, V31, P283, DOI [10.7555/JBR.30.20160060, 10.7555/JBR.31.20160060]

[3] Core Mutations in Patients With Acute Episodes of Chronic HBV Infection Are Associated With the Emergence of New Immune Recognition Sites and the Development of High IgM Anti-HBc Index Values [J].

Alexopoulou, Alexandra ;

Baltayiannis, Gerassimos ;

Eroglu, Cafer ;

Nastos, Theodoros ;

Dourakis, Spyros P. ;

Archimandritis, Athanasios J. ;

Karayiannis, Peter .

JOURNAL OF MEDICAL VIROLOGY, 2009, 81 (01) :34-41

[4] Extracorporeal liver support in patients with liver failure: a systematic review and meta-analysis of randomized trials [J].

Alshamsi, Fayez ;

Alshammari, Khalil ;

Belley-Cote, Emilie ;

Dionne, Joanna ;

Albrahim, Talal ;

Albudoor, Budoor ;

Ismail, Mona ;

Al-judaibi, Bandar ;

Baw, Bandar ;

Subramanian, Ram M. ;

Steadman, Randolph ;

Galusca, Dragos ;

Huang, David T. ;

Nanchal, Rahul ;

Al Quraini, Mustafa ;

Yuan, Yuhong ;

Alhazzani, Waleed .

INTENSIVE CARE MEDICINE, 2020, 46 (01) :1-16

[5] Chronic hepatitis B virus carriers in the immunotolerant phase of infection:: Histologic findings and outcome [J].

Andreani, Tony ;

Serfaty, Lawrence ;

Mohand, Djamila ;

Dernaika, Salem ;

Wendum, Dominique ;

Chazouilleres, Olivier ;

Poupon, Raoul .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2007, 5 (05) :636-641

[6] Liver transplantation in the most severely ill cirrhotic patients: A multicenter study in acute-on-chronic liver failure grade 3 [J].

Artru, Florent ;

Louvet, Alexandre ;

Ruiz, Isaac ;

Levesque, Eric ;

Labreuche, Julien ;

Ursic-Bedoya, Jose ;

Lassailly, Guillaume ;

Dharancy, Sebastien ;

Boleslawski, Emmanuel ;

Lebuffe, Gilles ;

Kipnis, Eric ;

Ichai, Philippe ;

Coilly, Audrey ;

De Martin, Eleonora ;

Antonini, Teresa Maria ;

Vibert, Eric ;

Jaber, Samir ;

Herrerro, Astrid ;

Samuel, Didier ;

Duhamel, Alain ;

Pageaux, Georges-Philippe ;

Mathurin, Philippe ;

Saliba, Faouzi .

JOURNAL OF HEPATOLOGY, 2017, 67 (04) :708-715

[7] Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-on-chronic liver failure: The RELIEF trial [J].

Banares, Rafael ;

Nevens, Frederik ;

Larsen, Fin Stolze ;

Jalan, Rajiv ;

Albillos, Agustin ;

Dollinger, Matthias ;

Saliba, Faouzi ;

Sauerbruch, Tilman ;

Klammt, Sebastian ;

Ockenga, Johann ;

Pares, Albert ;

Wendon, Julia ;

Bruennler, Tanja ;

Kramer, Ludwig ;

Mathurin, Philippe ;

de la Mata, Manuel ;

Gasbarrini, Antonio ;

Muellhaupt, Beat ;

Wilmer, Alexander ;

Laleman, Wim ;

Eefsen, Martin ;

Sen, Sambit ;

Zipprich, Alexander ;

Tenorio, Teresa ;

Pavesi, Marco ;

Schmidt, Hartmut H. -J. ;

Mitzner, Steffen ;

Williams, Roger ;

Arroyo, Vicente .

HEPATOLOGY, 2013, 57 (03) :1153-1162

[8] Role of interleukin-23 in monocyte-derived dendritic cells of HBV-related acute-on-chronic liver failure and its correlation with the severity of liver damage [J].

Bao, Suxia ;

Zheng, Jianming ;

Li, Ning ;

Huang, Chong ;

Chen, Mingquan ;

Cheng, Qi ;

Li, Qian ;

Lu, Qing ;

Zhu, Mengqi ;

Ling, Qingxia ;

Yu, Kangkang ;

Chen, Shengshen ;

Shi, Guangfeng .

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, 2017, 41 (02) :147-155

[9] Two core promotor mutations identified in a hepatitis B virus strain associated with fulminant hepatitis result in enhanced viral replication [J].

Baumert, TF ;

Rogers, SA ;

Hasegawa, K ;

Liang, TJ .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (10) :2268-2276

[10] Microbial Infections as a Trigger for Acute-onChronic Liver Failure: A Review [J].

Cai, Qun ;

Liu, Wei ;

Zhu, Mingyan ;

Sheng, Jifang .

MEDICAL SCIENCE MONITOR, 2019, 25 :4773-4783

← 1 2 3 4 5 6 7 8 9 10 →