Immunohistological study of endothelin-1 and endothelin-A and B receptors in two patients with scleroderma renal crisis

被引：47

作者：

Kobayashi, H

Nishimaki, T

Kaise, S

Suzuki, T

Watanabe, K

Kasukawa, R

Suzuki, T

机构：

[1] Fukushima Med UNiv, Sch Med, Dept Internal Med 2, Fukushima 9601295, Japan

[2] Fukushima Med UNiv, Sch Med, Dept Pathol 2, Fukushima 9601295, Japan

来源：

CLINICAL RHEUMATOLOGY | 1999年 / 18卷 / 05期

关键词：

scleroderma renal crisis and endothelin-1; systemic sclerosis;

D O I：

10.1007/s100670050132

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Scleroderma renal crisis (SRC) developed in two patients with systemic sclerosis (SSc) and they died from respiratory failure. Findings on autopsy revealed congestion and oedema in both lungs and intimal thickening of the small renal arteries in both patients. Immunohistological investigations showed positive staining of anti-human endothelin (ET)-1 in the media of the small renal arteries and ET-B receptor in the medial smooth muscle of the small renal arteries. This observation suggests an important pathophysiological role of ET-1 in the development of SRC in some patients with SSc.

引用

页码：425 / 427

页数：3

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