Microtubule-targeting Anticancer Agents from Marine Natural Substance

被引：14

作者：

Liu, Zhiguo ^{[1
]}

Xu, Pengfei ^{[1
]}

Wu, Tao ^{[2
]}

Zeng, Wenbin ^{[1
]}

机构：

[1] Cent S Univ, Sch Pharmaceut Sci, Changsha 410013, Hunan, Peoples R China

[2] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2014年 / 14卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Anticancer; marine; microtubule; natural products; ADVANCED SOLID MALIGNANCIES; ANALOG ERIBULIN MESYLATE; METASTATIC BREAST-CANCER; PHASE-I TRIAL; EVERY; 21; DAYS; HALICHONDRIN-B; ANTINEOPLASTIC AGENTS; STABILIZING AGENT; COLCHICINE SITE; PELORUSIDE-A;

D O I：

10.2174/187152061403140207163402

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Effective novel therapeutics is urgently needed due to increasing incidence of malignant cancer and drug multi-resistance. Natural products and their derivatives have historically been a source of pharmaceutical leads and therapeutic drugs. Microtubule-targeting compounds are among the most promising candidates in the combat against cancer. In particular, marine natural products (MNPs) have demonstrated exceptional potency and potential as anticancer agents. Drug discovery from MNPs provides a new pathway to develop original anticancer agents. In this review, seven classes of typical MNPs with diverse structures are summarized. Bioactive marine compounds isolated from different organisms including invertebrate animals, algae, fungi and bacteria are also discussed.

引用

页码：409 / 417

页数：9

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