Synthesis of a novel series of artemisinin dimers with potent anticancer activity involving Sonogashira cross-coupling reaction

被引：35

作者：

Buragohain, Pori ^{[1
]}

Saikia, Bishwajit ^{[1
]}

Surineni, Naresh ^{[1
]}

Barua, Nabin C. ^{[1
]}

Saxena, Ajit K. ^{[2
]}

Suri, Nitasha ^{[2
]}

机构：

[1] CSIR, North East Inst Sci & Technol, Nat Prod Chem Div, Jorhat 785006, Assam, India

[2] Indian Inst Integrat Med, Div Pharmacol, Jammu 180001, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 01期

关键词：

Artemisinin; Sonogashira cross-coupling; Artemisinin dimer; Anticancer; Dihydroartemisinin; CEM LEUKEMIA-CELLS; IN-VITRO; TRIOXANE DIMERS; ANTIMALARIAL ARTESUNATE; ANTITUMOR ACTIVITIES; DERIVATIVES; CYTOTOXICITY; GROWTH; DIHYDROARTEMISININ; INHIBITION;

D O I：

10.1016/j.bmcl.2013.11.032

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of C-10 acetal artemisinin dimers were synthesized using Sonogashira cross-coupling reaction. All these novel semisynthetic artemisinin dimers exhibited excellent growth inhibitory activity against Lung A-549 human cancer cell line. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：237 / 239

页数：3

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