Synthesis of a novel series of artemisinin dimers with potent anticancer activity involving Sonogashira cross-coupling reaction

被引：35
|
作者：
Buragohain, Pori [1 ]
Saikia, Bishwajit [1 ]
Surineni, Naresh [1 ]
Barua, Nabin C. [1 ]
Saxena, Ajit K. [2 ]
Suri, Nitasha [2 ]
机构：
[1] CSIR, North East Inst Sci & Technol, Nat Prod Chem Div, Jorhat 785006, Assam, India
[2] Indian Inst Integrat Med, Div Pharmacol, Jammu 180001, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 01期
关键词：
Artemisinin; Sonogashira cross-coupling; Artemisinin dimer; Anticancer; Dihydroartemisinin; CEM LEUKEMIA-CELLS; IN-VITRO; TRIOXANE DIMERS; ANTIMALARIAL ARTESUNATE; ANTITUMOR ACTIVITIES; DERIVATIVES; CYTOTOXICITY; GROWTH; DIHYDROARTEMISININ; INHIBITION;
D O I：
10.1016/j.bmcl.2013.11.032
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of C-10 acetal artemisinin dimers were synthesized using Sonogashira cross-coupling reaction. All these novel semisynthetic artemisinin dimers exhibited excellent growth inhibitory activity against Lung A-549 human cancer cell line. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：237 / 239
页数：3
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