Pathophysiological models of mixed states

被引：0

作者：

Belzeaux, R. ^{[1
]}

Ibrahim, E. C. ^{[2
]}

Azorin, J. -M. ^{[1
]}

Fakra, E. ^{[1
]}

Maurel, M. ^{[1
]}

Pringuey, D. ^{[3
]}

Kaladjian, A. ^{[4
]}

Dassa, D. ^{[5
]}

Correard, N. ^{[1
]}

Dubois, E. ^{[1
]}

Micoulaud-Franchi, J. -A. ^{[1
]}

Cermolacce, M. ^{[1
]}

机构：

[1] Hop St Marguerite, SHU Psychiat Adultes Solaris, F-13274 Marseille 09, France

[2] Aix Marseille Univ, CNRS, CRN2M, UMR 7286, Marseille, France

[3] CHU Pasteur, Clin Psychiat & Psychol Med, F-06002 Nice, France

[4] CHU Robert Debre, F-51092 Reims, France

[5] Hop Conception, Pole Psychiat Ctr, F-13006 Marseille, France

来源：

ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE | 2013年 / 39卷

关键词：

Bipolar disorders; Temperament; Comorbidity; BIPOLAR I DISORDER; MANIA;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mixed states are complex manifestations of bipolar disorders. Pathophysiology of mixed states remains unclear. Several models have been proposed to understand the mechanisms underlying these mood states. These models describe mixed state either as a combinaison of depression and mania, as well as a transition between mania and depression, or mixed state as a severe type of depression or mania. Pathophysiological hypotheses involve temperaments or some personality disorders, psychiatric comorbidities as well as substance use disorders, or thyroid dysfunction. However, the formal demonstration of any specific genetic vulnerability to mixed state has not yet been provided. (C) L'Encephale, Paris, 2013. All rights reserved.

引用

页码：S167 / S171

页数：5

共 23 条

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