Oxidative stress, mitochondrial damage and neurodegenerative diseases

被引:1066
作者
Guo, Chunyan [1 ]
Sun, Li [2 ]
Chen, Xueping [3 ]
Zhang, Danshen [4 ]
机构
[1] Hebei North Univ, Dept Pharm, Zhangjiakou 075000, Hebei Province, Peoples R China
[2] Hebei North Univ, Life Sci Res Ctr, Zhangjiakou 075000, Hebei Province, Peoples R China
[3] Univ Manitoba, Dept Human Anat & Cell Sci, Winnipeg, MB R3E 0J9, Canada
[4] Hebei Univ Sci & Technol, Shijiazhuang 050018, Hebei Province, Peoples R China
基金
中国国家自然科学基金;
关键词
neural regeneration; neurodegenerative diseases; Alzheimer's disease; Parkinson's disease; amyotrophic lateral sclerosis; oxidative stress; reactive oxygen species; mitochondrial damage; respiratory chain; grants-supported paper; neuroregeneration;
D O I
10.3969/j.issn.1673-5374.2013.21.009
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Oxidative stress and mitochondrial damage have been implicated in the pathogenesis of several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Oxidative stress is characterized by the overproduction of reactive oxygen species, which can induce mitochondrial DNA mutations, damage the mitochondrial respiratory chain, alter membrane permeability, and influence Ca2+ homeostasis and mitochondrial defense systems. All these changes are implicated in the development of these neurodegenerative diseases, mediating or amplifying neuronal dysfunction and triggering neurodegeneration. This paper summarizes the contribution of oxidative stress and mitochondrial damage to the onset of neurodegenerative diseases and discusses strategies to modify mitochondrial dysfunction that may be attractive therapeutic interventions for the treatment of various neurodegenerative diseases.
引用
收藏
页码:2003 / 2014
页数:12
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