Artemisia asiatica Nakai Attenuates the Expression of Proinflammatory Mediators in Stimulated Macrophages Through Modulation of Nuclear Factor-κB and Mitogen-Activated Protein Kinase Pathways

被引：2

作者：

Kim, Eun-Kyung ^{[1
,2
]}

Tang, Yujiao ^{[1
,2
]}

Cha, Kwang-Suk ^{[3
]}

Choi, Heeri ^{[3
]}

Lee, Chun Bok ^{[4
]}

Yoon, Jin-Hwan ^{[5
]}

Kim, Sang Bae ^{[6
]}

Kim, Jong-Shik ^{[7
]}

Kim, Jong Moon ^{[8
]}

Han, Weon Cheol ^{[9
]}

Choi, Suck-Jun ^{[10
]}

Lee, Sangmin ^{[11
]}

Choi, Eun-Ju ^{[3
]}

Kim, Sang-Hyun ^{[12
]}

机构：

[1] Konkuk Univ, Coll Biomed & Hlth Sci, Div Food Bio Sci, Chungju 380702, South Korea

[2] Konkuk Univ, Korea Nokyong Res Ctr, Chungju 380702, South Korea

[3] Konkuk Univ, Coll Sci & Technol, Div Sport Sci, Chungju 380702, South Korea

[4] Youngsan Univ, Dept Korean Food & Culinary Arts, Busan, South Korea

[5] Hannam Univ, Inst Nat Sci Res, Taejon, South Korea

[6] Kangwon Natl Univ, Div Sports Sci, Chunchon, South Korea

[7] Wonkwang Univ, Dept Sports Ind & Welf, Jeonbuk, South Korea

[8] Konkuk Univ, Chungju Hosp, Dept Phys Med & Rehabil, Chungbuk, South Korea

[9] Wonkwang Univ, Sanbon Med Ctr, Dept Pathol, Sanbon, South Korea

[10] Wonkwang Hlth Sci Univ, Dept Med Noncommissioned Officer, Jeonbuk, South Korea

[11] Seoul Natl Univ, Dept Ind Engn, Seoul, South Korea

[12] Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Lab Immunotoxicol, Daegu, South Korea

来源：

JOURNAL OF MEDICINAL FOOD | 2015年 / 18卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

Artemisia asiatica; Nakai; ERK1; 2; p38; NF-B; NITRIC-OXIDE SYNTHASE; LIPOPOLYSACCHARIDE-INDUCED EXPRESSION; SIGNAL-REGULATED KINASE; GENE-EXPRESSION; PHORBOL ESTER; ALPHA; INHIBITION; INDUCTION; EUPATILIN; EXTRACT;

D O I：

10.1089/jmf.2014.3344

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The present study aimed to examine the anti-inflammatory effects and potential mechanism of action of Artemisia asiatica Nakai (A. asiatica Nakai) extract in activated murine macrophages. A. asiatica Nakai extract showed dose-dependent suppression of lipopolysaccharide (LPS)-induced nitric oxide, inducible nitric oxide synthase, and cyclooxygenase-2 activity. It also showed dose-dependent inhibition of nuclear factor-B (NF-B) translocation from the cytosol to the nucleus and as an inhibitor of NF-B-alpha phosphorylation. The extract's inhibitory effects were found to be mediated through NF-B inhibition and phosphorylation of extracellular signal-regulated kinase 1/2 and p38 in LPS-stimulated J774A.1 murine macrophages, suggesting a potential mechanism for the anti-inflammatory activity of A. asiatica Nakai. To our knowledge, this is the first report of the anti-inflammatory effects of A. asiatica Nakai on J774A.1 murine macrophages; these results may help develop functional foods possessing an anti-inflammatory activity.

引用

页码：921 / 928

页数：8

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