Curcumin and Liver Disease: from Chemistry to Medicine

被引:184
作者
Nabavi, Seyed Fazel [1 ]
Daglia, Maria [2 ]
Hajizadeh Moghaddam, Akbar [3 ,4 ]
Habtemariam, Solomon [5 ]
Nabavi, Seyed Mohammad [1 ]
机构
[1] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran, Iran
[2] Univ Pavia, Dept Drug Sci, Med Chem & Pharmaceut Technol Sect, I-27100 Pavia, Italy
[3] Amol Univ Special Modern Technol, Amol, Iran
[4] Univ Mazandaran, Fac Basic Sci, Dept Biol, Babol Sar, Iran
[5] Univ Greenwich, Pharmacognosy Res Labs, Medway Sch Sci, Chatham ME4 4TB, Kent, England
关键词
antioxidant; curcumin; hepatic disorders; nuclear factor-kB; turmeric; NF-KAPPA-B; HEPATITIS-C VIRUS; INDUCED OXIDATIVE STRESS; PRIMARY SCLEROSING CHOLANGITIS; ENDOPLASMIC-RETICULUM STRESS; FERRITIN HEAVY-CHAIN; HEPATOCELLULAR-CARCINOMA; INDUCED APOPTOSIS; DOWN-REGULATION; TGF-BETA;
D O I
10.1111/1541-4337.12047
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Curcumin, the natural yellow-colored active principle, also called turmeric yellow, extracted from the perennial herb Curcuma longa L., has potent biological and pharmacological properties such as antioxidant, anti-inflammatory, antifungal, antibacterial, anti-ischemic, antitumor, and anticancer actions. The molecular mechanism of the hepatoprotective action of curcumin is due to its antioxidant properties and inhibitory activity against nuclear factor (NF)-B that regulates different proinflammatory and profibrotic cytokines. Overall, scientific reports demonstrate that curcumin has high therapeutic ability for treating hepatic disorders. Here is a systematic discussion of the hepatoprotective activity of curcumin and its possible mechanisms of actions.
引用
收藏
页码:62 / 77
页数:16
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