Substance P enhances HIV-1 infection in human fetal brain cell cultures expressing full-length neurokinin-1 receptor

被引：5

作者：

Schwartz, Lynnae ^{[1
]}

Spitsin, Sergei V. ^{[1
,2
]}

Meshki, John ^{[1
,2
]}

Tuluc, Florin ^{[1
,2
]}

Douglas, Steven D. ^{[1
,2
]}

Wolfe, John H. ^{[1
,2
,3
]}

机构：

[1] Childrens Hosp Philadelphia, Res Inst, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Vet Med, WF Goodman Ctr Comparat Med Genet, Philadelphia, PA 19104 USA

来源：

JOURNAL OF NEUROVIROLOGY | 2013年 / 19卷 / 03期

关键词：

Substance P; Human fetal brain cells; Neurokinin-1; receptor; HIV-1; Aprepitant; VIRUS TYPE-1 INFECTION; PROGENITOR CELLS; ANTAGONIST APREPITANT; CHEMOKINE RECEPTORS; ASTROCYTES; ACTIVATION; MATURATION; MICROGLIA; SYSTEM; NESTIN;

D O I：

10.1007/s13365-013-0166-x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The associations between the neurokinin-1 receptor (NK-1R), substance P (SP), and HIV-1 were investigated in neurosphere-derived cultures of microglial-depleted human fetal brain cells (HFBC). Full-length NK-1R was identified in HFBC cultures. SP treatment of the HFBC increased intracellular calcium mobilization and decreased electrical impedance, both of which were blocked by the NK-1R antagonist aprepitant. SP treatment of HIV-1-infected HFBC upregulated HIV-1 expression. These data show that human neural cells grown from neurospheres express functional full length NK-1R that is responsive to SP, and that SP enhanced HIV-1 infection in HBFC.

引用

页码：219 / 227

页数：9

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