Inhibition of bacterial growth by synthetic SP-B1-78 peptides

被引：26

作者：

Kaser, MR

Skouteris, GG

机构：

[1] UNIV CALIF SAN FRANCISCO, DEPT PEDIAT, SAN FRANCISCO, CA 94143 USA

[2] DEUTSCH KREBSFORSCHUNGSZENTRUM, RES PROGRAM APPL TUMOR VIROL, D-6900 HEIDELBERG, GERMANY

来源：

PEPTIDES | 1997年 / 18卷 / 09期

关键词：

SURFACTANT PROTEIN-B; ANTIMICROBIAL ACTIVITY; DERMASEPTIN-B; SEQUENCE; SEGMENT; DOMAIN;

D O I：

10.1016/S0196-9781(97)00211-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Residues 12-34 of mature human pulmonary surfactant protein B (SP-B1-78) are 68% homologous to residues 48-72 of the frog peptide antibiotic dermaseptin b I. We examined the effects of SP-B1-78 on the growth of Escherichia coli in order to find whether full length SP-B1-78 might act as a peptide antibiotic. We found that SP-B1-78 peptide inhibited growth Of E. coli (MIG = 210 mu g.ml(-1)), but that the SP-B variant [R/K --> S]SP-B1-78 was less potent (MIC = 500 lambda g.ml(-1)). (C) 1997 Elsevier Science Inc.

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收藏

页码：1441 / 1444

页数：4

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