Heparin induced thrombocytopenia: review

被引：8

作者：

Dasararaju, Radhika ^{[1
]}

Singh, Nirupama ^{[1
]}

Mehta, Amitkumar ^{[2
]}

机构：

[1] Univ Alabama Birmingham, Dept Transfus Med, Birmingham, AL 35249 USA

[2] Univ Alabama Birmingham, Dept Hematol & Oncol, Birmingham, AL 35294 USA

来源：

EXPERT REVIEW OF HEMATOLOGY | 2013年 / 6卷 / 04期

关键词：

argatroban; danaparoid; desirudin; fondaparinux; heparin; heparin-induced thrombocytopenia; HIT; lepirudin; thrombocytopenia; 4T score; MOLECULAR-WEIGHT HEPARIN; RECOMBINANT HIRUDIN; TISSUE FACTOR; ANTIBODIES; THROMBOSIS; RISK; PLATELET-FACTOR-4; DIAGNOSIS; LEPIRUDIN; HIT;

D O I：

10.1586/17474086.2013.814446

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heparin induced thrombocytopenia (HIT) is a serious, potentially life and limb threatening immune adverse reaction to heparin. IgG antibodies against platelet factor 4 and heparin multimer complexes activate platelets to create a prothrombotic state. ELISA based immunoassay to detect these antibodies is sensitive while serotonin release assay is highly specific but is not widely available. 4T score is a simple score to calculate pre-test probability of HIT. Score <3 is highly specific to exclude the diagnosis. Alternate anticoagulants like lepirudin, argatroban or danaparoid are recommended in therapeutic dose to treat or prevent thrombotic events in HIT. Increased awareness of this condition among clinicians is important to ensure its early recognition and treatment to avoid serious complications.

引用

页码：419 / 428

页数：10

共 78 条

[1] Evaluation of automated immunoassays in the diagnosis of heparin induced thrombocytopenia [J].

Althaus, Karina ;

Hron, Gregor ;

Strobel, Ulrike ;

Abbate, Rosanna ;

Rogolino, Angela ;

Davidson, Simon ;

Greinacher, Andreas ;

Bakchoul, Tamam .

THROMBOSIS RESEARCH, 2013, 131 (03) :E85-E90

[2] How I treat heparin-induced thrombocytopenia and thrombosis [J].

Alving, BM .

BLOOD, 2003, 101 (01) :31-37

[3] Antibodies from patients with heparin-induced thrombocytopenia stimulate monocytic cells to express tissue factor and secrete interleukin-8 [J].

Arepally, GM ;

Mayer, IM .

BLOOD, 2001, 98 (04) :1252-1254

[4] Recent advances in the diagnosis and treatment of heparin-induced thrombocytopenia [J].

Bakchoul, Tamam ;

Greinacher, Andreas .

THERAPEUTIC ADVANCES IN HEMATOLOGY, 2012, 3 (04) :237-251

[5]

Bambrah Ramandeep K, 2011, Clin Adv Hematol Oncol, V9, P594

[6] Thrombosis in Suspected Heparin-induced Thrombocytopenia Occurs More Often with High Antibody Levels [J].

Baroletti, Steven ;

Hurwitz, Shelley ;

Conti, Nicole A. S. ;

Fanikos, John ;

Piazza, Gregory ;

Goldhaber, Samuel Z. .

AMERICAN JOURNAL OF MEDICINE, 2012, 125 (01) :44-49

[7] Heparin-induced thrombocytopenia [J].

Chong, BH .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2003, 1 (07) :1471-1478

[8]

Cines Douglas B, 2004, Hematology Am Soc Hematol Educ Program, P390

[9] The HIT Expert Probability (HEP) Score: a novel pre-test probability model for heparin-induced thrombocytopenia based on broad expert opinion [J].

Cuker, A. ;

Arepally, G. ;

Crowther, M. A. ;

Rice, L. ;

Datko, F. ;

Hook, K. ;

Propert, K. J. ;

Kuter, D. J. ;

Ortel, T. L. ;

Konkle, B. A. ;

Cines, D. B. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2010, 8 (12) :2642-2650

[10] Predictive value of the 4Ts scoring system for heparin-induced thrombocytopenia: a systematic review and meta-analysis [J].

Cuker, Adam ;

Gimotty, Phyllis A. ;

Crowther, Mark A. ;

Warkentin, Theodore E. .

BLOOD, 2012, 120 (20) :4160-4167

← 1 2 3 4 5 6 7 8 →