Mapping and Role of the CD8+ T Cell Response During Primary Zika Virus Infection in Mice

被引：202

作者：

Ngono, Annie Elong ^{[1
]}

Vizcarra, Edward A. ^{[1
]}

Tang, William W. ^{[1
]}

Sheets, Nicholas ^{[1
]}

Joo, Yunichel ^{[1
]}

Kim, Kenneth ^{[1
]}

Gorman, Matthew J. ^{[2
]}

Diamond, Michael S. ^{[2
]}

Shresta, Sujan ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol, Div Inflammat Biol, La Jolla, CA 92037 USA

[2] Washington Univ, Sch Med, Ctr Human Immunol & Immunotherapy Programs, Dept Med Mol Microbiol Pathol & Immunol, St Louis, MO 63110 USA

来源：

CELL HOST & MICROBE | 2017年 / 21卷 / 01期

关键词：

DENGUE HEMORRHAGIC-FEVER; SEXUAL TRANSMISSION; PROTECTIVE ROLE; WESTERN-HEMISPHERE; MOUSE MODELS; DISEASE; PATHOGENESIS; REPLICATION; INTERFERON; ANTIBODIES;

D O I：

10.1016/j.chom.2016.12.010

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

CD8(+) T cells may play a dual role in protection against and pathogenesis of flaviviruses, including Zika virus (ZIKV). We evaluated the CD8(+) T cell response in ZIKV-infected LysMCre(+)IFNAR(fl/fl) C57BL/6 (H-2(b)) mice lacking the type I interferon receptor in a subset ofmyeloid cells. In total, 26 and 15CD8(+) T cell-reactive peptides for ZIKV African (MR766) and Asian (FSS13025) lineage strains, respectively, were identified and validated. CD8(+) T cells from infected mice were polyfunctional and mediated cytotoxicity. Adoptive transfer of ZIKV-immune CD8(+) T cells reduced viral burdens, whereas their depletion led to higher tissue burdens, and CD8(-/-) mice displayed highermortality with ZIKV infection. Collectively, these results demonstrate that CD8(+) T cells protect against ZIKV infection. Further, this study provides a T cell competent mouse model for investigating ZIKV-specific T cell responses.

引用

页码：35 / 46

页数：12

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