Remote magnetically controlled drug release from electrospun composite nanofibers: design of a smart platform for therapy of psoriasis

被引：6

作者：

Babincova, Natalia ^{[2
,3
]}

Jirsak, Oldrich ^{[4
]}

Babincova, Melania ^{[1
]}

Babinec, Peter ^{[1
]}

Simaljakova, Maria ^{[2
,3
]}

机构：

[1] Comenius Univ, Dept Nucl Phys & Biophys, Fac Math Phys & Informat, Mlynska Dolina F1, Bratislava 84248, Slovakia

[2] Comenius Univ, Fac Med, Dept Dermatovenereol, Mickiewiczova 13, Bratislava 81369, Slovakia

[3] Bratislava Univ Hosp, Mickiewiczova 13, Bratislava 81369, Slovakia

[4] Tech Univ Liberec, Fac Text Engn, Dept Nonwoven Text & Nanofibrous Mat, Halkova 6, Liberec 46117, Czech Republic

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION A-A JOURNAL OF PHYSICAL SCIENCES | 2020年 / 75卷 / 07期

关键词：

composite materials; drug release; electrospinning; nanoparticles; nanofibers; INTEGRATED CHEMOTHERAPY; HYPERTHERMIA; MAGNETOLIPOSOMES; TEXTILE;

D O I：

10.1515/zna-2020-0087

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

An efficient method for the large-scale fabrication of composite polyvinyl alcohol polymer nano fibers loaded with magnetic nanoparticles and methotrexate is reported in this study. We have demonstrated that nonwoven textile formed by needleless electro spinning is effective in immobilization and triggered the release of drugs, which is achieved by an alternating magnetic field induced heating of magnetic nanoparticles. This smart stimuli-responsive release ability, biocompatibility, and ultra-lightweight property render enormous potential for this electrospun nano fiber mat to be used as an anti-psoriatic drugs release platform, which may have far-reaching applications in dermatology.

引用

收藏

页码：587 / 591

页数：5

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