Synthesis & Biological Evaluation of Novel Series of Benzo[f]indazole Derivatives

被引：7
|
作者：
Hamdoon, Ahmed M. [1 ]
Saleh, Mohanad Y. [2 ]
Saied, Shakir Mahmood [3 ]
机构：
[1] Univ Mosul, Coll Agr & Forestry, Branch Basic Sci, Mosul, Iraq
[2] Univ Mosul, Coll Educ pure Sci, Dept Chem, Mosul, Iraq
[3] Al Noor Univ Coll, Dept Med Labs Technol, Barttella, Iraq
来源：
EGYPTIAN JOURNAL OF CHEMISTRY | 2022年 / 65卷 / 11期
关键词：
Benzo[f]indazole; Biological Evaluation; Chalgone; - keto ester; INDAZOLES; CYCLOHEXENONES; 2H-INDAZOLES;
D O I：
10.21608/EJCHEM.2022.120818.5418
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new series of benzo[f]indazole derivatives was synthesized via cyclo-condensation of beta-ketoester with arylidenes derivatives in the presence of alcoholic sodium hydroxide to afford octahydronaphthalene-2-carboxylates. 1,3-Dipolar cycloaddition between these carboxylates and hydrazine hydrate to form benzo[f]indazole derivatives. New obtained compounds were characterized upon elemental and spectroscopic analyses. Antibacterial activity of selected derivatives was evaluated.
引用
收藏
页码：305 / 312
页数：8
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