5-HT1 and 5-HT2 Receptors Are Involved in the Anxiolytic-Like Effects of the Neuronal NOS Inhibitor TRIM in the Rat

被引：0

作者：

Tanyeri, Pelin ^{[1
]}

Mutlu, Oguz ^{[2
]}

Ulak, Guner ^{[2
]}

Akar, Furuzan Yildiz ^{[2
]}

Celikyurt, Ipek Komsuoglu ^{[2
]}

Erden, Bekir Faruk ^{[2
]}

机构：

[1] Sakarya Univ, Fac Med, Dept Pharmacol, TR-54100 Sakarya, Turkey

[2] Kocaeli Univ, Fac Med, Dept Pharmacol, TR-41380 Kocaeli, Turkey

来源：

DRUG DEVELOPMENT RESEARCH | 2013年 / 74卷 / 04期

关键词：

anxiety; elevated plus-maze test; nitric oxide; TRIM; serotonergic system; OXIDE SYNTHASE INHIBITORS; NITRIC-OXIDE; 1-(2-TRIFLUOROMETHYLPHENYL) IMIDAZOLE; ANTIDEPRESSANT-LIKE; ACUTE FLUOXETINE; PLUS-MAZE; ANXIETY; ADRENOMEDULLIN;

D O I：

10.1002/ddr.21074

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Preclinical Research TRIM, a selective neuronal NOS inhibitor, had anxiolytic effects in the elevated plus-maze (EPM) test. The aim of the present study was to evaluate the involvement of serotonergic system in the anxiolytic-like effect of TRIM in the EPM test, a widely used animal model of anxiety. The anxiolytic-like effect of TRIM (50mg/kg, i.p.) in adult Wistar albino male rats in the EPM test was antagonized by pretreatment with the 5-HT depleting agent; parachlorophenylalanine methyl ester (3x150mg/kg i.p.) that inhibits 5-HT synthesis; methiothepin (0.1mg/kg, i.p.), a nonselective 5-HT receptor antagonist; WAY 100635 (0.1mg/kg i.p.), a selective 5-HT1A receptor antagonist; GR 127935 (3mg/kg i.p.), a selective 5-HT1B/1D receptor antagonist; cyproheptadine (3mg/kg i.p.), a 5-HT2 receptor antagonist; or ketanserin (5mg/kg i.p.), a 5-HT2A/2C receptor antagonist. The anxiolytic-like effects of TRIM thus appear to be mediated in part by 5-HT1 and 5-HT2 receptors.

引用

页码：242 / 251

页数：10

共 25 条

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