Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics

被引：140

作者：

Kim, Sung Bong ^{[1
,2
]}

Zhang, Yi ^{[4
,5
]}

Won, Sang Min ^{[1
,2
]}

Bandodkar, Amay J. ^{[4
,5
]}

Sekine, Yurina ^{[6
]}

Xue, Yeguang ^{[7
,9
]}

Koo, Jahyun ^{[4
,5
]}

Harshman, Sean W. ^{[10
]}

Martin, Jennifer A. ^{[10
]}

Park, Jeong Min ^{[11
,12
]}

Ray, Tyler R. ^{[4
,5
]}

Crawford, Kaitlyn E. ^{[1
,2
,3
]}

Lee, Kyu-Tae ^{[1
,2
]}

Choi, Jungil ^{[4
,5
]}

Pitsch, Rhonda L.

Grigsby, Claude C. ^{[10
]}

Strang, Adam J. ^{[13
]}

Chen, Yu-Yu ^{[1
,2
]}

Xu, Shuai ^{[14
,15
]}

Kim, Jeonghyun ^{[16
]}

Koh, Ahyeon ^{[17
]}

Ha, Jeong Sook ^{[18
]}

Huang, Yonggang ^{[8
,9
]}

Kim, Seung Wook ^{[18
,20
]}

Rogers, John A. ^{[4
,5
,9
,19
,20
,21
,22
,23
,24
]}

机构：

[1] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA

[2] Univ Illinois, Frederick Seitz Mat Res Lab, Urbana, IL 61801 USA

[3] Univ Cent Florida, Dept Mat Sci & Engn, Orlando, FL 32816 USA

[4] Northwestern Univ, Querry Inst BioNanotechnol, Ctr Biointegrated Elecctron Simpson, Evanston, IL 60208 USA

[5] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA

[6] Japan Atom Energy Agcy, Mat Sci Res Ctr, Tokai, Ibaraki 3191195, Japan

[7] Northwestern Univ, Dept Civil & Environm Engn, Evanston, IL 60208 USA

[8] Northwestern Univ, Dept Mat Sci & Engn, Dept Mech Engn, Dept Civil & Environm Engn, Evanston, IL 60208 USA

[9] Northwestern Univ, Dept Mech Engn, Evanston, IL 60208 USA

[10] US Air Force, Human Performance Wing 711, Human Ctr ISR Div, Human Signatures Branch,Res Labs,Airman Syst Dire, Wright Patterson AFB, OH 45433 USA

[11] Duke Univ, Dept Phys, Durham, NC 27708 USA

[12] Duke Univ, Dept Chem, Durham, NC 27708 USA

[13] US Air Force, Res Lab, Wright Patterson AFB, OH 45433 USA

[14] Northwestern Univ, Ctr Biointegrated Elect, Evanston, IL 60208 USA

[15] Northwestern Univ, Feinberg Sch Med, Dept Dermatol, Chicago, IL 60611 USA

[16] Kwangwoon Univ, Dept Elect Convergence Engn, Seoul 01897, South Korea

[17] SUNY Binghamton, Dept Biomed Engn, Binghamton, NY 13902 USA

[18] Korea Univ, Dept Chem & Biol Engn, Seoul 02841, South Korea

[19] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

[20] Northwestern Univ, Dept Chem, 2145 Sheridan Rd, Evanston, IL 60208 USA

[21] Northwestern Univ, Dept Elect Engn & Comp Sci, Evanston, IL 60208 USA

[22] Northwestern Univ, Dept Neurol Surg, Evanston, IL 60208 USA

[23] Northwestern Univ, McCormick Sch Engn, Simpson Querrey Inst Nano Biotechnol, Evanston, IL 60208 USA

[24] Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA

来源：

SMALL | 2018年 / 14卷 / 12期

关键词：

microfluidics; perspiration; super absorbent polymer; sweat chloride; CYSTIC-FIBROSIS; CHELATION; SENSOR; IRON; ION;

D O I：

10.1002/smll.201703334

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This paper introduces super absorbent polymer valves and colorimetric sensing reagents as enabling components of soft, skin-mounted microfluidic devices designed to capture, store, and chemically analyze sweat released from eccrine glands. The valving technology enables robust means for guiding the flow of sweat from an inlet location into a collection of isolated reservoirs, in a well-defined sequence. Analysis in these reservoirs involves a color responsive indicator of chloride concentration with a formulation tailored to offer stable operation with sensitivity optimized for the relevant physiological range. Evaluations on human subjects with comparisons against ex situ analysis illustrate the practical utility of these advances.

引用

页数：11

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