Spinal Cryptococcoma in an Immunocompetent Cat

被引：21

作者：

Belluco, S. ^{[1
]}

Thibaud, J. L. ^{[2
]}

Guillot, J. ^{[3
]}

Krockenberger, M. B. ^{[4
]}

Wyers, M. ^{[1
]}

Blot, S. ^{[2
]}

Colle, M. A. ^{[1
]}

机构：

[1] Ecole Natl Vet Nantes, INRA ENVN, UMR 703, Anat Pathol Unit, Nantes, France

[2] Ecole Natl Vet Alfort, Neurobiol Lab, Unite Neurol, Maisons Alfort, France

[3] Ecole Natl Vet Alfort, Unite Parasitol, Maisons Alfort, France

[4] Univ Sydney, Fac Vet Sci, Sydney, NSW 2006, Australia

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2008年 / 139卷 / 04期

关键词：

cat; cryptococcosis; Cryplococcus neoformans; spinal cord;

D O I：

10.1016/j.jcpa.2008.06.007

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

This report describes an unusual case of primary cryptococcoma in the proximal thoracic spinal cord of an 11-year-old immunocompetent cat from a farm on which there were large numbers of pigeons. This animal was referred for examination with progressive paralysis and shown to be free from feline immunodeficiency virus, feline leukaemia virus, feline coronavirus and Toxoplasma gondii. It died 2 months later. At necropsy, the only lesion detected was a malacic area, 4 cm in length, in the spinal cord. Histopathological examination of the spinal cord revealed severe granulomatous inflammation associated with large numbers of encapsulated yeast cells. In addition to the granulomatous host response, necrosis, digestion chambers, Gitter cells, spheroids and lymphocytic perivascular cuffs were features of the malacic areas. Immunohistochemistry confirmed the presence of Cryptococcus neoformans var. grubii yeast cells. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：246 / 251

页数：6

共 24 条

[1] Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans [J].

Bahn, YS ;

Kojima, K ;

Cox, GM ;

Heitman, J .

MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (05) :2285-2300

[2]

BAKER RD, 1976, AM J CLIN PATHOL, V65, P83

[3] Cryptococcal meningitis [J].

Bicanic, T ;

Harrison, TS .

BRITISH MEDICAL BULLETIN, 2005, 72 (01) :99-118

[4]

CASWELL JL, 2007, PATHOLOGY DOMESTIC A, V2, P642

[5] Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in Australia and New Zealand [J].

Chen, S ;

Sorrell, T ;

Nimmo, G ;

Speed, B ;

Currie, B ;

Ellis, D ;

Marriott, D ;

Pfeiffer, T ;

Parr, D ;

Byth, K .

CLINICAL INFECTIOUS DISEASES, 2000, 31 (02) :499-508

[6] Investigation of the basis of virulence in serotype A strains of Cryptococcus neoformans from apparently immunocompetent individuals [J].

D'Souza, CA ;

Hagen, F ;

Boekhout, T ;

Cox, GM ;

Heitman, J .

CURRENT GENETICS, 2004, 46 (02) :92-102

[7] Virulence profile of strains of Cryptococcus neoformans var. grubii evaluated by experimental infection in BALB/c mice and correlation with exoenzyme activity [J].

da Silva, EG ;

Baroni, FD ;

Viani, FC ;

Ruiz, LD ;

Gandra, RF ;

Auler, ME ;

Dias, ALT ;

Gambale, W ;

Paula, CR .

JOURNAL OF MEDICAL MICROBIOLOGY, 2006, 55 (02) :139-142

[8] The poor prognosis of central nervous system cryptococcosis among nonimmunosuppressed patients: A call for better disease recognition and evaluation of adjuncts to antifungal therapy [J].

Ecevit, IZ ;

Clancy, CJ ;

Schmalfuss, IM ;

Nguyen, MH .

CLINICAL INFECTIOUS DISEASES, 2006, 42 (10) :1443-1447

[9] Cryptococcus neoformans var. grubii:: Separate varietal status for Cryptococcus neoformans serotype A isolates [J].

Franzot, SP ;

Salkin, IF ;

Casadevall, A .

JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (03) :838-840

[10]

Ganter P., 1970, Histochimie Normale et Pathologique, VVolume 2

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