Characterization of splicing variants of histamine H3 receptor

被引：0
|
作者：
Tanaka, K [1 ]
Nakamura, T [1 ]
Itadani, H [1 ]
Takimura, T [1 ]
Hidaka, Y [1 ]
Ohta, M [1 ]
机构：
[1] Banyu Pharmaceut Co Ltd, Tsukuba Res Inst, Tsukuba, Ibaraki 3002611, Japan
来源：
HISTAMINE RESEARCH IN THE NEW MILLENNIUM | 2001年 / 1224卷
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D O I：
暂无
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
We found several splicing variants of the histamine H3 receptor (H3R) mRNA in human and rat. We characterized their profiles in the ligand binding and functional responses. All splicing variants-expressing cells, except one type, bound to [3 H]-N-alpha-methylhistamine (NAMHA) and responded to histamine (HA), inhibiting forskolin-induced cAMP accumulation. Marked differences of binding and functional profiles between the splicing variants were not observed.
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页码：377 / 382
页数：6
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