The gut microbiota and mucosal T cells

被引：72
作者：
Smith, Patrick M. [1 ,2 ]
Garrett, Wendy S. [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA
[4] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
[5] Broad Inst MIT & Harvard, Cambridge, MA USA
来源：
FRONTIERS IN MICROBIOLOGY | 2011年 / 2卷
关键词：
gut microbiota; T cells; mucosal immunity;
D O I：
10.3389/fmicb.2011.00111
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
It is intuitive that immune cells in the gut may require microbiota-derived cues for their differentiation. The proximity between host and microbe in the intestine would seemingly necessitate co-adaptation. However, it has been challenging to determine the members and features of the gut microbiota that influence immune system development and function. The recent identification of immunomodulatory members of the commensal microbiota is providing insight into the dependence of select, intestinal immune cell subsets on specific microbial species. In this review, we focus on the gut microbiota's influence on the development and function of mucosal T cells subsets, specifically intraepithelial lymphocytes and lamina propria CD4 T cells.
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页数：6
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