Biotransformation of dietary phytoestrogens by gut microbes: A review on bidirectional interaction between phytoestrogen metabolism and gut microbiota

被引:51
作者
Hameed, Ahkam Saddam Seyed [1 ]
Rawat, Parkash Singh [1 ]
Meng, Xiangfeng [1 ]
Liu, Weifeng [1 ]
机构
[1] Shandong Univ, Microbial Technol Inst, State Key Lab Microbial Technol, 72 Binhai Rd, Qingdao 266237, Peoples R China
基金
国家重点研发计划; 中国国家自然科学基金; 中国博士后科学基金;
关键词
Phytoestrogens; Gut microbial biotransformation; Modulation of gut microbiota; Bidirectional relationship; Gut bacteria isolation; Xenobiotic metabolism; HOPS HUMULUS-LUPULUS; HUMAN INTESTINAL BACTERIUM; 8-PRENYLNARINGENIN IN-VITRO; EQUOL-PRODUCING BACTERIUM; LACTIC-ACID BACTERIA; BREAST-CANCER RISK; ELLAGIC ACID; MAMMALIAN LIGNANS; S-EQUOL; SP-NOV;
D O I
10.1016/j.biotechadv.2020.107576
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Phytoestrogens are a class of plant produced polyphenolic compounds with diphenolic structure, which is similar to 17 beta-estradiol. These phytoestrogens preferentially bind to estrogen receptors, however, with weak affinity. Recently, many studies have found that these phytoestrogens can be transformed by gut microbiota through novel enzymatic reactions into metabolites with altered bioactivity. Recent studies have also implied that these metabolites could possibly modulate the host gut ecosystem, gene expression, metabolism and the immune system. Thus, isolating gut microbes capable of biotransforming phytoestrogens and characterizing the novel enzymatic reactions involved are principal to understand the mechanisms of beneficial effects brought by gut microbiota and their metabolism on phytoestrogens, and to provide the theoretical knowledge for the development of functional probiotics. In the present review, we summarized works on gut microbial biotransformation of phytoestrogens, including daidzin (isoflavone), phenylnaringenin (prenylflavonoid), lignans, resveratrol (stilbene) and ellagitannins. We mainly focus on gut bacterial isolation, metabolic pathway characterization, and the bidirectional interaction of phytoestrogens with gut microbes to illustrate the novel metabolic capability of gut microbiota and the methods used in these studies.
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页数:22
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