Simple Precision Creation of Digitally Specified, Spatially Heterogeneous, Engineered Tissue Architectures

被引：58

作者：

Gurkan, Umut Atakan ^{[1
]}

Fan, Yantao ^{[1
]}

Xu, Feng ^{[1
]}

Erkmen, Burcu ^{[1
]}

Urkac, Emel Sokullu ^{[1
]}

Parlakgul, Gunes ^{[1
]}

Bernstein, Jacob ^{[2
,3
,4
]}

Xing, Wangli ^{[5
,6
]}

Boyden, Edward S. ^{[2
,3
,4
]}

Demirci, Utkan ^{[7
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Harvard MIT Hlth Sci & Technol,Div Biomed Engn, Bioacoustic MEMS Med BAMM Lab,Dept Med,Sch Med, Cambridge, MA 02139 USA

[2] MIT, Media Lab, Cambridge, MA 02139 USA

[3] MIT, McGovern Inst, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA

[4] MIT, Dept Biol Engn, Cambridge, MA 02139 USA

[5] Tsinghua Univ, Sch Med, Med Syst Biol Res Ctr, Beijing 100084, Peoples R China

[6] Natl Engn Res Ctr Beijing Biochip Technol, Beijing 102206, Peoples R China

[7] Harvard Univ, Brigham & Womens Hosp, Sch Med, Harvard MIT Hlth Sci & Technol, Cambridge, MA 02139 USA

来源：

ADVANCED MATERIALS | 2013年 / 25卷 / 08期

基金：

美国国家科学基金会;

关键词：

three-dimensional microfabrication; biomanufacturing; biofabrication; advanced manufacturing; tissue engineering; neural engineering; brain engineering; POLY(ETHYLENE GLYCOL)/POLY(L-LYSINE) HYDROGELS; IN-VITRO; STEREOLITHOGRAPHY; TECHNOLOGIES; CULTURE; SYSTEMS; MODELS; CELLS;

D O I：

10.1002/adma.201203261

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Complex architectures of integrated circuits are achieved through multiple layer photolithography, which has empowered the semiconductor industry. We adapt this philosophy for tissue engineering with a versatile, scalable, and generalizable microfabrication approach to create engineered tissue architectures composed of digitally specifiable building blocks, each with tuned structural, cellular, and compositional features. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1192 / 1198

页数：7

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