Practical Method for the Cu-Mediated Trifluoromethylation of Arylboronic Acids with CF3 Radicals Derived from NaSO2CF3 and tert-Butyl Hydroperoxide (TBHP)

被引：188
作者：
Ye, Yingda [1 ]
Kuenzi, Stefan A. [1 ]
Sanford, Melanie S. [1 ]
机构：
[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 19期
关键词：
ARYL BORONIC ACIDS; OXIDATIVE TRIFLUOROMETHYLATION; FLUORINE; ARENES; CATALYSIS;
D O I：
10.1021/ol3022726
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mild and practical protocol for the copper-mediated trifluoromethylation of aryl and heteroaryl boronic acids using NaSO2CF3 (Langlois' reagent) and TBHP is described. The reaction proceeds at room temperature under ambient conditions, and the products can be readily purified by extraction or column chromatography.
引用
收藏
页码：4979 / 4981
页数：3
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