Clinical surrogate markers for predicting metabolic syndrome in middle-aged and elderly Chinese

被引：75

作者：

Li, Rui ^{[1
]}

Li, Qi ^{[1
]}

Cui, Min ^{[2
]}

Yin, Zegang ^{[2
]}

Li, Ling ^{[2
]}

Zhong, Tingting ^{[2
]}

Huo, Yingchao ^{[2
]}

Xie, Peng ^{[1
,3
,4
]}

机构：

[1] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China

[2] Third Mil Med Univ, Dept Neurol, Daping Hosp, Chongqing, Peoples R China

[3] Chongqing Med Univ, Inst Neurosci, Chongqing, Peoples R China

[4] Chongqing Med Univ, Collaborat Innovat Ctr Brain Sci, Chongqing, Peoples R China

来源：

JOURNAL OF DIABETES INVESTIGATION | 2018年 / 9卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Fasting triglycerides and glucose; Lipid accumulation product; Metabolic syndrome; VISCERAL ADIPOSITY INDEX; LIPID-ACCUMULATION PRODUCT; FASTING GLUCOSE; TYG INDEX; TRIGLYCERIDES; STATEMENT; RISK; VAI; FAT;

D O I：

10.1111/jdi.12708

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims/IntroductionThe present study evaluated the ability of lipid accumulation product (LAP), visceral adiposity index (VAI), and the product of triglycerides and glucose (TyG), three novel markers, in identifying metabolic syndrome (MetS) with different criteria in middle-aged and elderly Chinese. Materials and MethodsDuring June 2012 to January 2013, 992 consecutive patients (age 40years) were enrolled at Daping Hospital. The criteria of MetS were based on the International Diabetes Federation and the modified National Cholesterol Education Program's Adult Treatment PanelIII. VAI, LAP and TyG were computed based on a published mathematical model. ResultsThe prevalence of MetS was 42.8%. The receiver operating characteristic curve found LAP, VAI and TyG were positively related to MetS in both criteria. The optimal cut-offs of VAI, LAP and TyG for the modified National Cholesterol Education Program's Adult Treatment PanelIII and International Diabetes Federation criteria were 2.015, 31.465 and 8.706, and 2.035, 37.99 and 8.697, respectively. After adjustment of potential confounding factors, VAI, LAP and TyG were significantly correlated with MetS in all criteria according to optimal cut-offs. For MetS, reliable predictive value was observed in different subgroups (age and sex). LAP showed the greatest area under the curve in MetS with the International Diabetes Federation definition (area under the curve 0.887, 95% confidence interval 0.852-0.922). ConclusionsAP, VAI and TyG were reliable surrogate markers for identifying MetS in middle-aged and elderly Chinese. LAP could be a better parameter than VAI and TyG for predicting MetS in the present study.

引用

页码：411 / 418

页数：8

共 27 条

[1] Metabolic syndrome - a new world-wide definition. A consensus statement from the international diabetes federation [J].

Alberti, KGMM ;

Zimmet, P ;

Shaw, J .

DIABETIC MEDICINE, 2006, 23 (05) :469-480

[2] The metabolic syndrome - a new worldwide definition [J].

Alberti, KGMM ;

Zimmet, P ;

Shaw, J .

LANCET, 2005, 366 (9491) :1059-1062

[3] Visceral Adiposity Index A reliable indicator of visceral fat function associated with cardiometabolic risk [J].

Amato, Marco C. ;

Giordano, Carla ;

Galia, Massimo ;

Criscimanna, Angela ;

Vitabile, Salvatore ;

Midiri, Massimo ;

Galluzzo, Aldo .

DIABETES CARE, 2010, 33 (04) :920-922

[4] Applicability of visceral adiposity index in predicting metabolic syndrome in adults with obstructive sleep apnea: a cross-sectional study [J].

Chen, Gong-Ping ;

Qi, Jia-Chao ;

Wang, Bi-Ying ;

Lin, Xin ;

Zhang, Xiao-Bin ;

Zhao, Jian-Ming ;

Chen, Xiao Fang ;

Lin, Ting ;

Chen, Dong-Dong ;

Lin, Qi-Chang .

BMC PULMONARY MEDICINE, 2016, 16

[5] Lipid accumulation product: a simple and accurate index for predicting metabolic syndrome in Taiwanese people aged 50 and over [J].

Chiang, Jui-Kun ;

Koo, Malcolm .

BMC CARDIOVASCULAR DISORDERS, 2012, 12

[6] Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) [J].

Cleeman, JI ;

Grundy, SM ;

Becker, D ;

Clark, LT ;

Cooper, RS ;

Denke, MA ;

Howard, WJ ;

Hunninghake, DB ;

Illingworth, DR ;

Luepker, RV ;

McBride, P ;

McKenney, JM ;

Pasternak, RC ;

Stone, NJ ;

Van Horn, L ;

Brewer, HB ;

Ernst, ND ;

Gordon, D ;

Levy, D ;

Rifkind, B ;

Rossouw, JE ;

Savage, P ;

Haffner, SM ;

Orloff, DG ;

Proschan, MA ;

Schwartz, JS ;

Sempos, CT ;

Shero, ST ;

Murray, EZ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19) :2486-2497

[7] Clinical usefulness of lipid ratios, visceral adiposity indicators, and the triglycerides and glucose index as risk markers of insulin resistance [J].

Du, Tingting ;

Yuan, Gang ;

Zhang, Muxun ;

Zhou, Xinrong ;

Sun, Xingxing ;

Yu, Xuefeng .

CARDIOVASCULAR DIABETOLOGY, 2014, 13

[8] Applicatility of the visceral adiposity index (VAI) in the prediction of the components of the metabolic syndrome in elderly [J].

Goldani, Heloisa ;

Adami, Fernanda Scherer ;

Antunes, Maria Terezinha ;

Rosa, Luis Henrique ;

Fassina, Patricia ;

Quevedo Grave, Magali Terezinha ;

Dal Bosco, Simone Morelo .

NUTRICION HOSPITALARIA, 2015, 32 (04) :1609-1615

[9] Diagnosis and management of the metabolic syndrome - An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement [J].

Grundy, SM ;

Cleeman, JI ;

Daniels, SR ;

Donato, KA ;

Eckel, RH ;

Franklin, BA ;

Gordon, DJ ;

Krauss, RM ;

Savage, PJ ;

Smith, SC ;

Spertus, JA ;

Costa, F .

CIRCULATION, 2005, 112 (17) :2735-2752

[10] The Product of Triglycerides and Glucose, a Simple Measure of Insulin Sensitivity. Comparison with the Euglycemic-Hyperinsulinemic Clamp [J].

Guerrero-Romero, Fernando ;

Simental-Mendia, Luis E. ;

Gonzalez-Ortiz, Manuel ;

Martinez-Abundis, Esperanza ;

Ramos-Zavala, Maria G. ;

Hernandez-Gonzalez, Sandra O. ;

Jacques-Camarena, Omar ;

Rodriguez-Moran, Martha .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (07) :3347-3351

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