Adoptive immunotherapy for the treatment of glioblastoma: progress and possibilities

被引：8

作者：

Kuramitsu, Shunichiro ^{[1
]}

Yamamichi, Akane ^{[1
]}

Ohka, Fumiharu ^{[1
]}

Motomura, Kazuya ^{[1
]}

Hara, Masahito ^{[1
]}

Natsume, Atsushi ^{[1
]}

机构：

[1] Nagoya Univ, Sch Med, Dept Neurosurg, Showa Ku, 65 Tsurumai, Nagoya, Aichi 4668550, Japan

来源：

IMMUNOTHERAPY | 2016年 / 8卷 / 12期

关键词：

chimeric antigen receptor T cells; glioblastoma; immune modulators; T cell receptor gene-modified T cells; CHIMERIC ANTIGEN RECEPTOR; GROWTH-FACTOR RECEPTOR; MODIFIED T-CELLS; CANCER REGRESSION; GLIOMA-CELLS; STEM-CELLS; EXPRESSION; ANTIBODY; RECOGNITION; EGFRVIII;

D O I：

10.2217/imt-2016-0076

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Patients with glioblastoma have a very poor prognosis. Adoptive cellular therapy (ACT) is defined as the collection of circulating or tumor-infiltrating lymphocytes, their selection, modification, expansion and activation, and their re-administration to patients in order to induce antitumor activity. Although various ACTs have been attempted, most failed to improve the outcome. Immune checkpoint blockade antibodies and T cell engineering with tumor-specific chimeric antigen receptors suggest the emergence of a new era of immunotherapy. Here, we summarize approaches with ACTs using genetically modified T cells, which have been improved by enhancing their antitumor activity, and discuss strategies to develop these therapies. The mechanisms by which gliomas modulate and evade the immune system are also discussed.

引用

页码：1393 / 1404

页数：12

共 81 条

[1] Sequential Immunotherapy by Vaccination With GM-CSF-expressing Glioma Cells and CTLA-4 Blockade Effectively Treats Established Murine Intracranial Tumors [J].

Agarwalla, Pankaj ;

Barnard, Zachary ;

Fecci, Peter ;

Dranoff, Glenn ;

Curry, William T., Jr. .

JOURNAL OF IMMUNOTHERAPY, 2012, 35 (05) :385-389

[2]

Ahmed N., 2015, J. Immunother. Cancer, V3, pO11, DOI [10.1186/2051-1426-3-S2-O11, DOI 10.1186/2051-1426-3-S2-O11]

[3] HER2-Specific T Cells Target Primary Glioblastoma Stem Cells and Induce Regression of Autologous Experimental Tumors [J].

Ahmed, Nabil ;

Salsman, Vita S. ;

Kew, Yvonne ;

Shaffer, Donald ;

Powell, Suzanne ;

Zhang, Yi J. ;

Grossman, Robert G. ;

Heslop, Helen E. ;

Gottschalk, Stephen .

CLINICAL CANCER RESEARCH, 2010, 16 (02) :474-485

[4] Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy [J].

Bendle, Gavin M. ;

Linnemann, Carsten ;

Hooijkaas, Anna I. ;

Bies, Laura ;

de Witte, Moniek A. ;

Jorritsma, Annelies ;

Kaiser, Andrew D. M. ;

Pouw, Nadine ;

Debets, Reno ;

Kieback, Elisa ;

Uckert, Wolfgang ;

Song, Ji-Ying ;

Haanen, John B. A. G. ;

Schumacher, Ton N. M. .

NATURE MEDICINE, 2010, 16 (05) :565-U98

[5] Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma [J].

Berghoff, Anna Sophie ;

Kiesel, Barbara ;

Widhalm, Georg ;

Rajky, Orsolya ;

Ricken, Gerda ;

Woehrer, Adelheid ;

Dieckmann, Karin ;

Filipits, Martin ;

Brandstetter, Anita ;

Weller, Michael ;

Kurscheid, Sebastian ;

Hegi, Monika E. ;

Zielinski, Christoph C. ;

Marosi, Christine ;

Hainfellner, Johannes A. ;

Preusser, Matthias ;

Wick, Wolfgang .

NEURO-ONCOLOGY, 2015, 17 (08) :1064-1075

[6] Bioactivity and Safety of IL13Rα2-Redirected Chimeric Antigen Receptor CD8+ T Cells in Patients with Recurrent Glioblastoma [J].

Brown, Christine E. ;

Badie, Behnam ;

Barish, Michael E. ;

Weng, Lihong ;

Ostberg, Julie R. ;

Chang, Wen-Chung ;

Naranjo, Araceli ;

Starr, Renate ;

Wagner, Jamie ;

Wright, Christine ;

Zhai, Yubo ;

Bading, James R. ;

Ressler, Julie A. ;

Portnow, Jana ;

D'Apuzzo, Massimo ;

Forman, Stephen J. ;

Jensen, Michael C. .

CLINICAL CANCER RESEARCH, 2015, 21 (18) :4062-4072

[7] Glioma IL13Rα2 Is Associated with Mesenchymal Signature Gene Expression and Poor Patient Prognosis [J].

Brown, Christine E. ;

Warden, Charles D. ;

Starr, Renate ;

Deng, Xutao ;

Badie, Behnam ;

Yuan, Yate-Ching ;

Forman, Stephen J. ;

Barish, Michael E. .

PLOS ONE, 2013, 8 (10)

[8] Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival [J].

Brown, Scott D. ;

Warren, Rene L. ;

Gibb, Ewan A. ;

Martin, Spencer D. ;

Spinelli, John J. ;

Nelson, Brad H. ;

Holt, Robert A. .

GENOME RESEARCH, 2014, 24 (05) :743-750

[9] Temozolomide Does Not Impair Gene Therapy-Mediated Antitumor Immunity in Syngeneic Brain Tumor Models [J].

Candolfi, Marianela ;

Yagiz, Kader ;

Wibowo, Mia ;

Ahlzadeh, Gabrielle E. ;

Puntel, Mariana ;

Ghiasi, Homayon ;

Kamran, Neha ;

Paran, Christopher ;

Lowenstein, Pedro R. ;

Castro, Maria G. .

CLINICAL CANCER RESEARCH, 2014, 20 (06) :1555-1565

[10] Comprehensive genomic characterization defines human glioblastoma genes and core pathways [J].

Chin, L. ;

Meyerson, M. ;

Aldape, K. ;

Bigner, D. ;

Mikkelsen, T. ;

VandenBerg, S. ;

Kahn, A. ;

Penny, R. ;

Ferguson, M. L. ;

Gerhard, D. S. ;

Getz, G. ;

Brennan, C. ;

Taylor, B. S. ;

Winckler, W. ;

Park, P. ;

Ladanyi, M. ;

Hoadley, K. A. ;

Verhaak, R. G. W. ;

Hayes, D. N. ;

Spellman, Paul T. ;

Absher, D. ;

Weir, B. A. ;

Ding, L. ;

Wheeler, D. ;

Lawrence, M. S. ;

Cibulskis, K. ;

Mardis, E. ;

Zhang, Jinghui ;

Wilson, R. K. ;

Donehower, L. ;

Wheeler, D. A. ;

Purdom, E. ;

Wallis, J. ;

Laird, P. W. ;

Herman, J. G. ;

Schuebel, K. E. ;

Weisenberger, D. J. ;

Baylin, S. B. ;

Schultz, N. ;

Yao, Jun ;

Wiedemeyer, R. ;

Weinstein, J. ;

Sander, C. ;

Gibbs, R. A. ;

Gray, J. ;

Kucherlapati, R. ;

Lander, E. S. ;

Myers, R. M. ;

Perou, C. M. ;

McLendon, Roger .

NATURE, 2008, 455 (7216) :1061-1068

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