Secondary Metabolites from Two Species of Tolpis and Their Biological Activities

被引：4

作者：

Triana, Jorge ^{[1
]}

Lopez, Mariana ^{[1
]}

Javier Perez, Francisco ^{[1
]}

Rico, Milagros ^{[1
]}

Lopez, Aroa ^{[1
]}

Estevez, Francisco ^{[2
,3
]}

Teresa Marrero, Maria ^{[2
]}

Brouard, Ignacio ^{[4
]}

Leon, Francisco ^{[4
]}

机构：

[1] Univ Las Palmas Gran Canaria, CSIC, Unidad Asociada, Dept Quim, Las Palmas Gran Canaria 35017, Spain

[2] Univ Las Palmas Gran Canaria, CSIC, Unidad Asociada, Dept Bioquim, Las Palmas Gran Canaria 35016, Spain

[3] Fdn Canaria Inst Canario Invest Canc, San Cristobal La Laguna 38204, Sc De Tenerife, Spain

[4] CSIC, Inst Prod Nat & Agrobiol, San Cristobal la Laguna 38206, Spain

来源：

MOLECULES | 2012年 / 17卷 / 11期

关键词：

Asteraceae; Tolpis proustii; Tolpis lagopoda; ursane-triterpenes; taraxastane-triterpenes; TARAXASTANE-TYPE TRITERPENES; FICUS-MICROCARPA; AERIAL ROOTS; CHEMICAL-CONSTITUENTS; C-13; SPECTRA; H-1; ASSIGNMENT; DERIVATIVES; ASTERACEAE;

D O I：

10.3390/molecules171112895

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytochemical research of two Tolpis species, T. proustii and T. lagopoda, led to the isolation of three new compounds: 30-chloro-3 beta-acetoxy-22 alpha-hydroxyl-20(21)-taraxastene (1), 3 beta,22 alpha-diacetoxy-30-ethoxy-20(21)-taraxastene(2) and 3 beta,28-dihydroxy-11 alpha-hydroperoxy-12-ursene (3). The structures of the new compounds were elucidated by means of extensive IR, NMR, and MS data and by comparison of data reported in the literature. The in vitro antioxidant activities of the extracts were assessed by the DPPH and ABTS scavenging methods. The cytotoxicity of several known compounds and its derivatives was also assessed against human myeloid leukemia K-562 and K-562/ADR cell lines.

引用

页码：12895 / 12909

页数：15

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