T cell immunosenescence in vitro and in vivo

被引：67

作者：

Pawelec, G ^{[1
]}

Wagner, W ^{[1
]}

Adibzadeh, M ^{[1
]}

Engel, A ^{[1
]}

机构：

[1] Univ Tubingen, Med Klin & Poliklin,Dept Internal Med 2, Tubingen Ageing & Tumour Immunol Grp, Sect Transplantat Immunol & Immunohaematol, D-72076 Tubingen, Germany

来源：

EXPERIMENTAL GERONTOLOGY | 1999年 / 34卷 / 03期

关键词：

T cell longevity in vitro; T cell aging in vivo; DNA damage and repair; mitotic inhibitors; telomere attrition; apoptosis; cytokine secretion; CD28;

D O I：

10.1016/S0531-5565(99)00002-9

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The term "immunosenescence" refers to an age-associated dysregulation of immune function which contributes to the increased susceptibility of the elderly to infectious disease. Although there are age-associated changes measurable in the innate immune system (Pawelec et al., 1998c), it is the adaptive, particularly T cell, system which is most susceptible to the deleterious effects of aging. In this minireview, characteristics of aging in long-term human T cell cultures will be summarized, and the parallels between the in vitro model and in vivo immunosenescence will be documented. The use of culture models to screen for ways of manipulating immunosenescence in vitro may provide a basis for intervention to ameliorate immunosenescence in vivo. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：419 / 429

页数：11

共 56 条

[1] LONG-TERM CULTURE OF MONOCLONAL HUMAN T-LYMPHOCYTES - MODELS FOR IMMUNOSENESCENCE [J].