Nuclear and mitochondrial DNA mutation in human and canine tumors

被引：0

作者：

Slaska, Brygida ^{[1
]}

Grzybowska-Szatkowska, Ludmila ^{[2
]}

Bugno-Poniewierska, Monika ^{[3
,4
]}

Surdyka, Magdalena ^{[1
]}

Smiech, Anna ^{[5
]}

机构：

[1] Univ Life Sci Lublin, Fac Anim Breeding & Biol, Dept Biol Bases Anim Prod, PL-20950 Lublin, Poland

[2] Med Univ Lublin, Dept Oncol, PL-20090 Lublin, Poland

[3] Natl Res Inst Anim Prod, Lab Genom, PL-32083 Balice, Poland

[4] Univ Rzeszow, Dept Genet, PL-35959 Rzeszow, Poland

[5] Univ Life Sci Lublin, Fac Vet Med, Dept Pathol Anat, PL-20612 Lublin, Poland

来源：

MEDYCYNA WETERYNARYJNA-VETERINARY MEDICINE-SCIENCE AND PRACTICE | 2013年 / 69卷 / 04期

关键词：

mutations; genes; nDNA; mtDNA; cancer; GENOME-WIDE ASSOCIATION; BREAST-CANCER; PROTEIN EXPRESSION; CYTOCHROME-B; GENE; SUSCEPTIBILITY; RISK; RAD51; DOGS; POLYMORPHISMS;

D O I：

暂无

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Over the past few years, there has been a significant progress in genetic testing in dogs through the development of genomic maps, which make it possible to determine the background of polygenic genetic diseases. The information obtained by mapping the canine genome, a detailed marker map, and the understanding of genome architecture have changed the possibilities and direction of canine genetic research. It is now possible to understand the genomics of the qualitative and quantitative traits associated with the phenotype, genetic predisposition, and genetic background of canine defects and diseases. Investigations of canine genetic diseases are particularly valuable because their results can be used in human medicine. From the medical point of view, genetic diseases in both humans and dogs are similar, which makes it possible to test new therapeutic approaches in the case of orthologous genes containing mutations responsible for genetic disorders.

引用

页码：195 / 202

页数：8

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