Infections in early life and childhood leukaemia risk: a UK case-control study of general practitioner records

被引：39
作者：
Cardwell, C. R. [1 ,2 ]
McKinney, P. A. [3 ]
Patterson, C. C. [1 ]
Murray, L. J. [1 ,2 ]
机构：
[1] Queens Univ Belfast, Sch Med & Dent, Dept Epidemiol & Publ Hlth, Belfast BT12 6BJ, Antrim, North Ireland
[2] Queens Univ Belfast, Canc Epidemiol & Prevent Res Grp, Belfast BT12 6BJ, Antrim, North Ireland
[3] Univ Leeds, Ctr Biostat & Epidemiol, Paediat Epidemiol Grp, Leeds LS2 9JT, W Yorkshire, England
来源：
BRITISH JOURNAL OF CANCER | 2008年 / 99卷 / 09期
基金：
英国经济与社会研究理事会; 英国医学研究理事会;
关键词：
epidemiology; infection; leukaemia; acute; childhood;
D O I：
10.1038/sj.bjc.6604696
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We investigated infections in early life (diagnosed in general practice) and subsequent risk of childhood leukaemia in the UK General Practice Research Database (GPRD). All children born at GPRD practices and subsequently diagnosed with leukaemia were identified as cases and were individually matched (on year of birth, sex and practice) to up to 20 controls. The final analysis included 162 leukaemia cases and 2215 matched controls. Conditional logistic regression demonstrated no evidence that children with one or more recorded infection in the first year of life had a reduced risk of leukaemia (OR = 1.05, 95% CI = 0.69, 1.59; P = 0.83) or acute lymphoblastic leukaemia (ALL; OR 1.05, 95% CI 0.64 - 1.74; P = 0.84). Our study provides no support for the Greaves hypothesis, which proposes that reduced or delayed exposure to infections in early life increases the risk of childhood ALL.
引用
收藏
页码：1529 / 1533
页数：5
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