Total Synthesis of (+)-Aureol

被引：35

作者：

Kuan, Kevin K. W. ^{[1
]}

Pepper, Henry P. ^{[1
]}

Bloch, Witold M. ^{[1
]}

George, Jonathan H. ^{[1
]}

机构：

[1] Univ Adelaide, Sch Chem & Phys, Adelaide, SA 5005, Australia

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 18期

关键词：

A VIRUS SUBSTANCES; MARINE SPONGE; ACETYLSTACHYFLIN; (-)-NEOAVARONE; HYDROQUINONE; (+)-ARENAROL; METABOLITES; DERIVATIVES; STACHYFLIN; QUINONES;

D O I：

10.1021/ol301715u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A total synthesis of the marine sponge meroterpenoid (+)-aureol has been achieved in 12 steps (6% overall yield) from (+)-sclareolide. Key steps of the synthesis include a biosynthetically inspired sequence of 1,2-hydride and methyl shifts, and a biomimetic cycloetherification reaction.

引用

页码：4710 / 4713

页数：4

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