Tubulointerstitial nephritis and uveitis syndrome in a mother and her son

被引：16

作者：

Dusek, Jiri ^{[1
]}

Urbanova, Ivana ^{[2
]}

Stejskal, Josef ^{[3
]}

Seeman, Tomas ^{[1
]}

Vondrak, Karel ^{[1
]}

Janda, Jan ^{[1
]}

机构：

[1] Charles Univ Prague, Dept Pediat, Univ Hosp Motol, Sch Med 2, Prague 15000 5, Czech Republic

[2] Charles Univ Prague, Dept Pediat, Univ Hosp Bulovce, Prague 15000 5, Czech Republic

[3] Charles Univ Prague, Dept Pathol & Mol Med, Univ Hosp Motol, Sch Med 2, Prague 15000 5, Czech Republic

来源：

PEDIATRIC NEPHROLOGY | 2008年 / 23卷 / 11期

关键词：

familial idiopathic tubulointerstitial nephritis; uveitis;

D O I：

10.1007/s00467-008-0879-x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A mother and her son, both with tubulointerstitial nephritis and uveitis syndrome (TINU) are reported. The nephritis presented itself at 13 years in the mother and at 10 years in her son. Glomerular filtration (GFR) decreased in both, and renal biopsies confirmed the diagnosis. Nephritis preceded the onset of uveitis in both. Clinical course and renal function improved quickly on oral steroids in the boy. The mother's hyperazotemia decreased spontaneously (without steroids), but not to normal range, and remained stable for 35 years of follow-up. Local steroids due to recurrences of uveitis were repeatedly needed in both. We believe this is the first report on familial occurrence of inherited TINU syndrome in two generations.

引用

页码：2091 / 2093

页数：3

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