Chronic effect of thyroxine on behavior and brain serotonin receptors in mice with contrast predisposition to catalepsy

被引：0
作者：
Zubkov, E. A. [1 ]
Kulikov, A. V. [2 ]
Naumenko, V. S. [2 ]
Popova, N. K. [2 ]
机构：
[1] Novosibirsk State Univ, Novosibirsk, Russia
[2] Russian Acad Sci, Inst Cytol & Genet, Siberian Div, Novosibirsk 630090, Russia
来源：
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA | 2008年 / 58卷 / 04期
关键词：
thyroxine; catalepsy; 5-HT1A receptor; 5-HT2A receptor; mice;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Effects of chronic thyroxine treatment (2 mg/l, 60 days) on catalepsy, functional activity and expression of 5-HT1A and 5-HT2A receptors genes in the brain were studied in adult males of catalepsy-prone ASC and catalepsy-resistant AKR mouse strains. Thyroxine caused an appearance of cataleptics in AKR, but produced an anticataleptic effect on ASC mice. Chronic thyroxine treatment increased the functional activity and expression of 5-HT2A receptors in the frontal cortex in AKR, but not in ASC mice. Hormone markedly attenuated hypothermic effect of 8-OH-DPAT, 5-HT1A receptor agonist, but did not affect the expression of 5-HT1A receptors in ASC mice. The results suggest the involvement of the 5-HT2A receptors in the cataleptogenic and the 5-HT1A receptors in the anticataleptic effects of hormone.
引用
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页码：493 / 499
页数：7
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