Nanomedicine: pharmacological perspectives

被引：16

作者：

Bhattacharya, Santanu ^{[1
]}

Alkharfy, Khalid M. ^{[2
,3
]}

Janardhanan, Rajiv ^{[4
]}

Mukhopadhyay, Debabrata ^{[1
,5
]}

机构：

[1] Mayo Clin, Coll Med, Dept Biochem & Mol Biol, Rochester, MN 55905 USA

[2] King Saud Univ, Coll Pharm, Riyadh, Saudi Arabia

[3] King Saud Univ, Biomarkers Res Program, Riyadh, Saudi Arabia

[4] Mayo Clin, Dept Radiol, Rochester, MN 55905 USA

[5] Mayo Clin, Dept Biomed Engn, Rochester, MN 55905 USA

来源：

NANOTECHNOLOGY REVIEWS | 2012年 / 1卷 / 03期

基金：

美国国家卫生研究院;

关键词：

nanomedicine; pharmacodynamics; pharmacogenetics; pharmacokinetics; toxicity; SOLID LIPID NANOPARTICLES; LIPOSOME-BASED CARRIER; SUPERPARAMAGNETIC IRON-OXIDE; PLURONIC BLOCK-COPOLYMERS; POLYION COMPLEX MICELLES; WALLED CARBON NANOTUBES; IN-VIVO BIODISTRIBUTION; DRUG-DELIVERY SYSTEMS; SILICA NANOPARTICLES; CANCER-THERAPY;

D O I：

10.1515/ntrev-2011-0010

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rapid developments in the field of nanotechnology are generating enormous interest in prospecting the potential of multifunctional therapeutic nanovectors in the field of personalized medicine. Although the nanomaterials are of same dimensions to many cellular machineries, their interaction with cells, tissues and organs of the body are not well understood. This in turn forms the rationale for a comprehensive study of these nanoplatforms in various disease models in terms of their toxicity, pharmacokinetics, pharmacodynamics, and pharmacogenetics. Such a study will significantly aid in our quest in translating its application from bench to bedside.

引用

页码：235 / 253

页数：19

共 227 条

[1] EFFICACY AND SAFETY PROFILE OF GEMCITABINE IN NON-SMALL-CELL LUNG-CANCER - A PHASE-II STUDY [J].

ABRATT, RP ;

BEZWODA, WR ;

FALKSON, G ;

GOEDHALS, L ;

HACKING, D ;

RUGG, TA .

JOURNAL OF CLINICAL ONCOLOGY, 1994, 12 (08) :1535-1540

[2] Effects of nanomaterial physicochemical properties on in vivo toxicity [J].

Aillon, Kristin L. ;

Xie, Yumei ;

El-Gendy, Nashwa ;

Berkland, Cory J. ;

Forrest, M. Laird .

ADVANCED DRUG DELIVERY REVIEWS, 2009, 61 (06) :457-466

[3] Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation [J].

Akagi, D. ;

Oba, M. ;

Koyama, H. ;

Nishiyama, N. ;

Fukushima, S. ;

Miyata, T. ;

Nagawa, H. ;

Kataoka, K. .

GENE THERAPY, 2007, 14 (13) :1029-1038

[4] Toxicogenomics of non-viral drug delivery systems for RNAi: Potential impact on siRNA-mediated gene silencing activity and specificity [J].

Akhtar, Saghir ;

Benter, Ibrahim .

ADVANCED DRUG DELIVERY REVIEWS, 2007, 59 (2-3) :164-182

[5] A combinatorial library of lipid-like materials for delivery of RNAi therapeutics [J].

Akinc, Akin ;

Zumbuehl, Andreas ;

Goldberg, Michael ;

Leshchiner, Elizaveta S. ;

Busini, Valentina ;

Hossain, Naushad ;

Bacallado, Sergio A. ;

Nguyen, David N. ;

Fuller, Jason ;

Alvarez, Rene ;

Borodovsky, Anna ;

Borland, Todd ;

Constien, Rainer ;

de Fougerolles, Antonin ;

Dorkin, J. Robert ;

Jayaprakash, K. Narayanannair ;

Jayaraman, Muthusamy ;

John, Matthias ;

Koteliansky, Victor ;

Manoharan, Muthiah ;

Nechev, Lubomir ;

Qin, June ;

Racie, Timothy ;

Raitcheva, Denitza ;

Rajeev, Kallanthottathil G. ;

Sah, Dinah W. Y. ;

Soutschek, Juergen ;

Toudjarska, Ivanka ;

Vornlocher, Hans-Peter ;

Zimmermann, Tracy S. ;

Langer, Robert ;

Anderson, Daniel G. .

NATURE BIOTECHNOLOGY, 2008, 26 (05) :561-569

[6] Strategy for effective brain drug delivery [J].

Alam, M. Intakhab ;

Beg, Sarwar ;

Samad, Abdus ;

Baboota, Sanjula ;

Kohli, Kanchan ;

Ali, Javed ;

Ahuja, Alka ;

Akbar, M. .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2010, 40 (05) :385-403

[7] Factors affecting the clearance and biodistribution of polymeric nanoparticles [J].

Alexis, Frank ;

Pridgen, Eric ;

Molnar, Linda K. ;

Farokhzad, Omid C. .

MOLECULAR PHARMACEUTICS, 2008, 5 (04) :505-515

[8] LONG-CIRCULATING (STERICALLY STABILIZED) LIPOSOMES FOR TARGETED DRUG-DELIVERY [J].

ALLEN, TM .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1994, 15 (07) :215-220

[9] Is personalized medicine finally arriving? [J].

Allison, Malorye .

NATURE BIOTECHNOLOGY, 2008, 26 (05) :509-517

[10] Fullerene (C60) immunoconjugates:: interaction of water-soluble C60 derivatives with the murine anti-gp240 melanoma antibody [J].

Ashcroft, Jared M. ;

Tsyboulski, Dmitri A. ;

Hartman, Keith B. ;

Zakharian, Tatiana Y. ;

Marks, John W. ;

Weisman, R. Bruce ;

Rosenblum, Michael G. ;

Wilson, Lon J. .

CHEMICAL COMMUNICATIONS, 2006, (28) :3004-3006

← 1 2 3 4 5 6 7 8 9 10 →