Expanding Roles for SREBP in Metabolism

被引：448

作者：

Shao, Wei ^{[1
]}

Espenshade, Peter J. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Cell Biol, Baltimore, MD 21205 USA

来源：

CELL METABOLISM | 2012年 / 16卷 / 04期

基金：

美国国家卫生研究院;

关键词：

MTOR COMPLEX 1; LIPID-METABOLISM; HEPATIC STEATOSIS; PATHWAY; INHIBITION; INSULIN; MICE; LIPOGENESIS; ACTIVATION; PROTEIN;

D O I：

10.1016/j.cmet.2012.09.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sterol regulatory element-binding protein (SREBP) transcription factors regulate cellular lipogenesis and lipid homeostasis. Recent studies reveal expanding roles for SREBPs with the description of new regulatory mechanisms, the identification of unexpected transcriptional targets, and the discovery of functions for SREBPs in type II diabetes, cancer, immunity, neuroprotection, and autophagy.

引用

页码：414 / 419

页数：6

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