Synthesis of Tetrasubstituted Pyrazoles from Substituted Hydrazines and β-Keto Esters

被引：13

作者：

Bakanas, Ian J. ^{[1
]}

Moura-Letts, Gustavo ^{[1
]}

机构：

[1] Rowan Univ, Dept Chem & Biochem, 201 Mullica Hill Rd, Glassboro, NJ 08028 USA

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 2016卷 / 32期

关键词：

Tetrasubstituted pyrazoles; Pyrazolones; Nitrogen heterocycles; Cyclization; Reaction mechanisms; ONE-POT SYNTHESIS; ROOM-TEMPERATURE SYNTHESIS; BASE-MEDIATED REACTION; REGIOSELECTIVE SYNTHESIS; ESTROGEN-RECEPTOR; PROMOTED SYNTHESIS; N-ARYLPYRAZOLES; BUILDING-BLOCKS; DERIVATIVES; LIGANDS;

D O I：

10.1002/ejoc.201601093

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein we report the synthesis of tetrasubstituted pyrazoles from simple hydrazines and beta-keto esters under mild, basic conditions. This reaction enables the selective synthesis of pyrazolones, alkoxypyrazoles, and tetrasubstituted pyrazoles for a large variety of aromatic hydrazines and substituted beta-keto esters with high yields and selectivities. This method permits access to highly complex pyrazole scaffolds with four orthogonal diversification groups.

引用

页码：5345 / 5349

页数：5

共 61 条

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