Multiple Roles of Staphylococcus aureus Enterotoxins: Pathogenicity, Superantigenic Activity, and Correlation to Antibiotic Resistance

被引：142

作者：

Ortega, Elena ^{[1
]}

Abriouel, Hikmate ^{[1
]}

Lucas, Rosario ^{[1
]}

Galvez, Antonio ^{[1
]}

机构：

[1] Univ Jaen, Fac Ciencias Expt, Area Microbiol, Dept Ciencias Salud, Jaen 23071, Spain

来源：

TOXINS | 2010年 / 2卷 / 08期

关键词：

enterotoxins; Staphylococcus aureus; superantigens; MRSA; immune response; TOXIC-SHOCK-SYNDROME; PENICILLIN-BINDING PROTEIN; CLASS-II MOLECULES; METHICILLIN-RESISTANT; ANTIMICROBIAL RESISTANCE; CRYSTAL-STRUCTURE; CROSS-LINKING; HIGH-AFFINITY; T-CELLS; IDENTIFICATION;

D O I：

10.3390/toxins2082117

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Heat-stable enterotoxins are the most notable virulence factors associated with Staphylococcus aureus, a common pathogen associated with serious community and hospital acquired diseases. Staphylococcal enterotoxins (SEs) cause toxic shock-like syndromes and have been implicated in food poisoning. But SEs also act as superantigens that stimulate T-cell proliferation, and a high correlation between these activities has been detected. Most of the nosocomial S. aureus infections are caused by methicillin-resistant S. aureus (MRSA) strains, and those resistant to quinolones or multiresistant to other antibiotics are emerging, leaving a limited choice for their control. This review focuses on these diverse roles of SE, their possible correlations and the influence in disease progression and therapy.

引用

页码：2117 / 2131

页数：15

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