Total glucosides of peony attenuates experimental autoimmune encephalomyelitis in C57BL/6 mice

被引：8

作者：

Huang, Qiling ^{[1
]}

Ma, Xiaomeng ^{[1
]}

Zhu, Dong Liang ^{[1
]}

Chen, Li ^{[2
]}

Jiang, Ying ^{[1
]}

Zhou, Linli ^{[1
]}

Cen, Lei ^{[1
]}

Pi, Rongbiao ^{[3
]}

Chen, Xiaohong ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Neurol, Guangzhou 510630, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 3, Med Examinat Ctr, Guangzhou 510630, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Sch Pharmaceut Sci, Dept Pharmacol & Toxicol, Guangzhou 510630, Guangdong, Peoples R China

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 284卷

基金：

中国国家自然科学基金; 以色列科学基金会;

关键词：

Total glucosides of peony; Experimental autoimmune encephalomyelitis; Th1/Th17; Th2/Treg; Brain-derived neurotrophic factor; 2; 3 '-cyclic nucleotide 3 '-phosphodiesterase; 2,3-CYCLIC NUCLEOTIDE 3-PHOSPHODIESTERASE; CHRONIC UNPREDICTABLE STRESS; MULTIPLE-SCLEROSIS; NEUROTROPHIC FACTOR; T-CELLS; TRANSCRIPTION FACTOR; ADJUVANT ARTHRITIS; GENE-EXPRESSION; PAEONIFLORIN; BRAIN;

D O I：

10.1016/j.jneuroim.2015.05.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Total glucosides of peony (TGP), an active compound extracted from the roots of Paeonia lactiflora Pall, has wide pharmacological effects on nervous system. Here we examined the effects of TGP on experimental autoimmune encephalomyelitis (EAE), an established model of multiple sclerosis (MS). The results showed that TGP can reduce the severity and progression of EAE in C57 BL/6 mice. In addition, TGP also down-regulated the Th1/Th17 inflammatory response and prevented the reduced expression of brain-derived neurotrophic factor and 2',3'-cyclic nucleotide 3'-phosphodiesterase of EAE. These findings suggest that TGP could be a potential therapeutic agent for MS. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：67 / 73

页数：7

共 50 条

[31] Characterization of Relapsing-Remitting and Chronic Forms of Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice
Berard, Jennifer L.
Wolak, Kevin
Fournier, Sylvie
David, Samuel
GLIA, 2010, 58 (04) : 434 - 445
[32] Effect of aqueous extract of Achillea millefolium on the development of experimental autoimmune encephalomyelitis in C57BL/6 mice
Vazirinejad, Reza
Ayoobi, Fateme
Arababadi, Mohammad Kazemi
Eftekharian, Mohammad M.
Darekordi, Ali
Goudarzvand, Mahdi
Hassanshahi, Gholamhossein
Taghavi, Mohammad Mohsen
Ahmadabadi, Behzad Nasiri
Kennedy, Derek
Shamsizadeh, Ali
INDIAN JOURNAL OF PHARMACOLOGY, 2014, 46 (03) : 303 - 308
[33] Healing Influence of Melilotus Officinalis Herbal Extract on Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice
Hassani, Mahdieh
Soleimani, Maryam
Esmaeilzadeh, Emran
Zare-Abdollahi, Davood
Khorshid, Hamid Reza Khorram
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2020, 19 (04): : 321 - 329
[34] L-Selectin-deficient SJL and C57BL/6 mice are not resistant to experimental autoimmune encephalomyelitis
Uboldi, Chiara
Doering, Axinia
Alt, Carsten
Estess, Pila
Siegelman, Mark
Engelhardt, Britta
EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (08) : 2156 - 2167
[35] The role of the central dopamine depletion in regulation of experimental autoimmune encephalomyelitis in C57BL mice
Balkowiec-Iskra, E
Kurkowska-Jastrzebska, I
Joniec, I
Czlonkowska, A
Czlonkowski, A
JOURNAL OF NEUROIMMUNOLOGY, 2004, 154 (1-2) : 56 - 56
[36] Alleviation of Experimental Allergic Encephalomyelitis in C57BL/6 Mice by Soy Daidzein
Jahromi, Soodeh Razeghi
Arrefhosseini, Seyed Rafi
Ghaemi, Amir
Alizadeh, Akram
Tabriz, Hedieh Moradi
Togha, Mansoureh
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY, 2014, 13 (04) : 256 - 264
[37] Alleviation of experimental allergic encephalomyelitis in C57BL/6 mice by soy daidzein
Jahromi, Soodeh Razeghi
Togha, Mansoureh
Ghaemi, Amir
Alizadeh, Akram
Doosti, Rozita
Tabriz, Hedieh Moradi
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 2015, 47 : 108 - 108
[38] Effects of Intermittent Fasting on Experimental Autoimune Encephalomyelitis in C57BL/6 Mice
Jahromi, Soodeh Razeghi
Ghaemi, Amir
Alizadeh, Akram
Sabetghadam, Fatemeh
Tabriz, Hedieh Moradi
Togha, Mansoureh
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY, 2016, 15 (03) : 212 - 219
[39] Identifying Factors That Determine Disease Susceptibility in C57BL/6 Mice for Adoptive Transfer of Experimental Autoimmune Encephalomyelitis
Zacharias, Tresa E.
Ben, Li-Hong
Cravens, Petra D.
Zein, Sima
Eagar, Todd N.
Hussain, Rehana
Nessler, Stefan
Zamvil, Scott
Stuve, Olaf
NEUROLOGY, 2010, 74 (09) : A566 - A566
[40] An optimized and validated protocol for inducing chronic experimental autoimmune encephalomyelitis in C57BL/6J mice
Huntemann, Niklas
Vogelsang, Anna
Groeneweg, Linda
Willison, Alice
Herrmann, Alexander M.
Meuth, Sven G.
Eichler, Susann
JOURNAL OF NEUROSCIENCE METHODS, 2022, 367

← 1 2 3 4 5 →