Total glucosides of peony attenuates experimental autoimmune encephalomyelitis in C57BL/6 mice

被引：8

作者：

Huang, Qiling ^{[1
]}

Ma, Xiaomeng ^{[1
]}

Zhu, Dong Liang ^{[1
]}

Chen, Li ^{[2
]}

Jiang, Ying ^{[1
]}

Zhou, Linli ^{[1
]}

Cen, Lei ^{[1
]}

Pi, Rongbiao ^{[3
]}

Chen, Xiaohong ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Neurol, Guangzhou 510630, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 3, Med Examinat Ctr, Guangzhou 510630, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Sch Pharmaceut Sci, Dept Pharmacol & Toxicol, Guangzhou 510630, Guangdong, Peoples R China

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 284卷

基金：

中国国家自然科学基金; 以色列科学基金会;

关键词：

Total glucosides of peony; Experimental autoimmune encephalomyelitis; Th1/Th17; Th2/Treg; Brain-derived neurotrophic factor; 2; 3 '-cyclic nucleotide 3 '-phosphodiesterase; 2,3-CYCLIC NUCLEOTIDE 3-PHOSPHODIESTERASE; CHRONIC UNPREDICTABLE STRESS; MULTIPLE-SCLEROSIS; NEUROTROPHIC FACTOR; T-CELLS; TRANSCRIPTION FACTOR; ADJUVANT ARTHRITIS; GENE-EXPRESSION; PAEONIFLORIN; BRAIN;

D O I：

10.1016/j.jneuroim.2015.05.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Total glucosides of peony (TGP), an active compound extracted from the roots of Paeonia lactiflora Pall, has wide pharmacological effects on nervous system. Here we examined the effects of TGP on experimental autoimmune encephalomyelitis (EAE), an established model of multiple sclerosis (MS). The results showed that TGP can reduce the severity and progression of EAE in C57 BL/6 mice. In addition, TGP also down-regulated the Th1/Th17 inflammatory response and prevented the reduced expression of brain-derived neurotrophic factor and 2',3'-cyclic nucleotide 3'-phosphodiesterase of EAE. These findings suggest that TGP could be a potential therapeutic agent for MS. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：67 / 73

页数：7

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