Cryptococcus gattii Infections in Multiple States Outside the US Pacific Northwest

被引：58

作者：

Harris, Julie R. ^{[1
]}

Lockhart, Shawn R. ^{[1
]}

Sondermeyer, Gail ^{[2
]}

Vugia, Duc J. ^{[2
]}

Crist, Matthew B. ^{[3
]}

D'Angelo, Melissa Tobin ^{[3
]}

Sellers, Brenda ^{[4
]}

Franco-Paredes, Carlos ^{[4
,5
]}

Makvandi, Monear ^{[6
]}

Smelser, Chad ^{[6
]}

Greene, John ^{[7
]}

Stanek, Danielle ^{[8
]}

Signs, Kimberly ^{[9
]}

Nett, Randall J. ^{[1
,10
]}

Chiller, Tom ^{[1
]}

Park, Benjamin J. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA

[2] Calif Dept Publ Hlth, Richmond, CA USA

[3] Georgia Dept Publ Hlth, Atlanta, GA USA

[4] Phoebe Putney Mem Hosp, Albany, GA USA

[5] Hosp Infantil Federico Gomez, Mexico City, DF, Mexico

[6] New Mexico Dept Hlth, Santa Fe, NM USA

[7] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA

[8] Florida Dept Hlth, Tallahassee, FL USA

[9] Michigan Dept Community Hlth, Lansing, MI USA

[10] Montana Dept Publ Hlth & Human Serv, Helena, MT USA

来源：

EMERGING INFECTIOUS DISEASES | 2013年 / 19卷 / 10期

关键词：

NEOFORMANS VAR GATTII; HIV-UNINFECTED PATIENTS; EPIDEMIOLOGIC DIFFERENCES; HIGH PREVALENCE; VARIETIES; MENINGITIS; DISEASE; HOST;

D O I：

10.3201/eid1910.130441

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clonal VGII subtypes (outbreak strains) of Cryptococcus gattii have caused an outbreak in the US Pacific North-west since 2004. Outbreak-associated infections occur equally in male and female patients (median age 56 years) and usually cause pulmonary disease in persons with underlying medical conditions. Since 2009, a total of 25 C. gattii infections, 23 (92%) caused by non outbreak strain C. gattii, have been reported from 8 non Pacific Northwest states.-Sixteen (64%) patients were previously healthy, and 21(84%) were male; median age was 43 years (range 15-83 years). Ten patients who provided information reported no past-year travel to areas where C. gattii is known to be endemic. Nineteen (76%) patients had central nervous system infections; 6 (24%) died. C. gattii infection in persons without exposure to known disease-endemic areas suggests possible endemicity in the United States outside the outbreak-affected region; these infections appear to differ in clinical and demographic characteristics from outbreak-associated C. gattii. Clinicians outside the outbreak-affected areas should be aware of locally acquired C. gattii infection and its varied signs and symptoms.

引用

页码：1620 / 1626

页数：7

共 36 条

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