Deoxynucleic guanidine: synthesis and incorporation of purine nucleosides into positively charged DNG oligonucleotides

被引：17
|
作者：
Challa, H [1 ]
Bruice, TC [1 ]
机构：
[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 06期
基金：
美国国家卫生研究院;
关键词：
purines; DNG; positively charged; nucleic acid; guanidinium;
D O I：
10.1016/j.bmc.2003.12.043
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of purine nucleosides capable of making the guanidinium linkage is described for the first time starting from the corresponding 2'-deoxynucleosides. The positively charged mixed base DNG oligomer containing guanine was synthesized on solid-phase using CPG as support from 3' to 5' direction using the precursor building block nucleosides. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1475 / 1481
页数：7
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