Microwave-assisted preparation of fused bicyclic heteroaryl boronates: Application in one-pot Suzuki couplings

被引：28

作者：

DiMauro, EF ^{[1
]}

Vitullo, JR ^{[1
]}

机构：

[1] Amgen Inc, Dept Chem Res & Discovery, Cambridge, MA 02139 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 10期

关键词：

D O I：

10.1021/jo060218p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The rapid and efficient synthesis of various disubstituted 5,6-fused heterocycles using a microwave-assisted one-pot cyclization-Suzuki coupling approach is described. This work highlights the tolerance of the boronic ester functional group to a variety of reaction conditions and the utility of functionalized boronates as penultimate intermediates in the synthesis of diverse compound libraries.

引用

页码：3959 / 3962

页数：4

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